# ZNF703

Source: https://onco.cc/targets/znf703/  
OnCo record `znf703` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZNF703 (Zinc finger protein 703) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.

## Summary

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Letrozole and Ribociclib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger protein 703; Zinc finger protein 703; FLJ14299; ZNF503L; NLZ1; Zpo1; ZEPPO1
- Tags: cancer-genes-wave
- Symbol: ZNF703
- Class: transcription
- Biology: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. Location: Nucleus; Cytoplasm (UniProt). Locus 8p11.23 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25883: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25883
- UniProt Q9H7S9: https://www.uniprot.org/uniprotkb/Q9H7S9/entry
- NCBI Gene 80139: https://www.ncbi.nlm.nih.gov/gene/80139
- Ensembl ENSG00000183779: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183779

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

---
JSON: https://onco.cc/api/v1/entities/znf703.json