# ZNF750

Source: https://onco.cc/targets/znf750/  
OnCo record `znf750` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZNF750 (Zinc finger protein 750) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Oesophageal and junctional adenocarcinoma and Non-small-cell lung cancer.

## Summary

Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.96, animal model 0.39, genetic association 0.04, somatic mutation 0.81). IntOGen calls it a driver in 3 cohorts (0 activating, 3 loss-of-function), covering Oesophageal Adenocarcinoma, Lung Squamous Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger protein 750; Zinc finger protein 750; FLJ13841; Zfp750
- Tags: cancer-genes-wave
- Symbol: ZNF750
- Class: tumor-suppressor
- Biology: Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression. Location: Nucleus (UniProt). Locus 17q25.3 (HGNC).
- Where found: Oesophageal cancer: IntOGen driver in 2 cohorts (ESCA); Oesophageal and junctional adenocarcinoma: IntOGen driver in 2 cohorts (ESCA); Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25843: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25843
- UniProt Q32MQ0: https://www.uniprot.org/uniprotkb/Q32MQ0/entry
- NCBI Gene 79755: https://www.ncbi.nlm.nih.gov/gene/79755
- Ensembl ENSG00000141579: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141579

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Oesophageal and junctional adenocarcinoma](https://onco.cc/cancers/oesophageal-adenocarcinoma/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/)

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JSON: https://onco.cc/api/v1/entities/znf750.json