# ZXDB

Source: https://onco.cc/targets/zxdb/  
OnCo record `zxdb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ZXDB (Zinc finger X-linked protein ZXDB) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.

## Summary

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: zinc finger X-linked duplicated B; Zinc finger X-linked protein ZXDB; ZNF905
- Tags: cancer-genes-wave
- Symbol: ZXDB
- Class: tumor-suppressor
- Biology: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Location: Nucleus (UniProt). Locus Xp11.21 (HGNC).
- Where found: Breast cancer: IntOGen driver in 1 cohort (BRCA)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13199: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13199
- UniProt P98169: https://www.uniprot.org/uniprotkb/P98169/entry
- NCBI Gene 158586: https://www.ncbi.nlm.nih.gov/gene/158586
- Ensembl ENSG00000198455: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198455

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/zxdb.json