# Zyflamend (ten-herb formula)

Source: https://onco.cc/technologies/zyflamend/  
OnCo record `zyflamend` (Technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Zyflamend is a commercial blend of ten herbs marketed for healthy inflammation and sometimes used by men with prostate cancer. It slowed prostate cancer in animals, but in people there is only a small safety trial in a precancerous prostate condition and a few case reports, which do not show it works.

## Summary

Zyflamend is a dietary supplement containing ten herbal extracts, marketed for a healthy inflammation response and heart and joint function. Memorial Sloan Kettering's About Herbs summary describes antiproliferative effects in oral, pancreatic, melanoma and bladder cancer cells and slowed growth of hormone-sensitive and insensitive prostate cancer in an animal model. Human data are limited: a phase I trial in men with prostatic intraepithelial neoplasia found no serious adverse events and falls in C-reactive protein and NF-kappa-B, and a few cases of response to combination regimens including Zyflamend have been described in castration-resistant prostate cancer. MSK states more studies are warranted. Reported side effects are a bad taste, heartburn and diarrhoea. In preclinical work it added to the effects of gemcitabine, paclitaxel, doxorubicin and bicalutamide, and with ten herbs it can potentially interact with prescription drugs.

## Fields

- Kind: Technology
- Status: phase-2
- Last checked: 2026-11-04
- Tags: complementary; supportive-care; evidence:insufficient
- Principle: A mixture including turmeric, ginger, green tea, holy basil and others, with COX-inhibiting and anti-inflammatory constituents in laboratory models.
- Strengths: A phase 1 safety trial exists
- Limitations: No controlled efficacy trial; Ten-herb mixture with interaction potential; Clinical responses only as case reports

## Sources

- MSK About Herbs: Zyflamend (page last updated 20 January 2021): https://www.mskcc.org/cancer-care/integrative-medicine/herbs/zyflamend

## Connected records

- technologies: [Beta-elemene](https://onco.cc/technologies/beta-elemene/), [Curcumin and turmeric](https://onco.cc/technologies/curcumin-turmeric/), [Dietary supplements during cancer treatment: interactions and harms](https://onco.cc/technologies/dietary-supplements-treatment-interactions/), [Evidence-based integrative oncology](https://onco.cc/technologies/integrative-oncology/), [Ginger for chemotherapy nausea](https://onco.cc/technologies/ginger-nausea/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- fronts: [Supportive Care & Survivorship](https://onco.cc/fronts/supportive-care/)
- drugs: [Bicalutamide](https://onco.cc/drugs/bicalutamide/), [Doxorubicin](https://onco.cc/drugs/doxorubicin/), [Gemcitabine](https://onco.cc/drugs/gemcitabine/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/)
- bottlenecks: [Misinformation and unproven therapies](https://onco.cc/bottlenecks/b-misinformation/)

---
JSON: https://onco.cc/api/v1/entities/zyflamend.json