{"id":"kif18a","name":"KIF18A","symbol":"KIF18A","route":"/targets/kif18a/","asOf":"2026-11-03","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29441","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000121621","uniprot":"https://www.uniprot.org/uniprotkb/Q8NI77/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q8NI77","open-targets":"https://platform.opentargets.org/target/ENSG00000121621","civic":"https://civicdb.org/genes/81930/summary","oncokb":"https://www.oncokb.org/gene/KIF18A","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=KIF18A","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=KIF18A","depmap":"https://depmap.org/portal/gene/KIF18A?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000121621-KIF18A","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/81930","omim":"https://www.omim.org/entry/611271"}],"products":[{"id":"atx-295","name":"ATX-295","status":"phase-1","modality":"Oral small molecule","route":"/drugs/atx-295/"},{"id":"sovilnesib","name":"Sovilnesib","status":"phase-1","modality":"Small molecule, oral","route":"/drugs/sovilnesib/"},{"id":"vls-1488","name":"VLS-1488","status":"phase-1","modality":"Small molecule, oral","route":"/drugs/vls-1488/"}],"trials":[{"id":"nct06799065","name":"First-in-Human Study of ATX-295, an Oral Inhibitor of KIF18A, as Monotherapy and in Combination With Anticancer Therapy in Patients With Advanced or Metastatic Solid Tumors, Including Ovarian Cancer","nct":"NCT06799065","phase":"1/2","status":"recruiting"},{"id":"nct06084416","name":"A Study of Sovilnesib in Subjects With Ovarian Cancer","nct":"NCT06084416","phase":"1","status":"recruiting"},{"id":"nct04293094","name":"Study of AMG 650 in Adult Participants With Advanced Solid Tumors","nct":"NCT04293094","phase":"1","status":"completed"}],"pathways":[],"companies":["accent-therapeutics","volastra-therapeutics"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}