{"id":"polq","name":"POLQ","symbol":"POLQ","route":"/targets/polq/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9186","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000051341","uniprot":"https://www.uniprot.org/uniprotkb/O75417/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/O75417","open-targets":"https://platform.opentargets.org/target/ENSG00000051341","civic":"https://civicdb.org/genes/10721/summary","oncokb":"https://www.oncokb.org/gene/POLQ","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=POLQ","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=POLQ","depmap":"https://depmap.org/portal/gene/POLQ?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000051341-POLQ","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/10721","omim":"https://www.omim.org/entry/604419"}],"products":[{"id":"dat-1604","name":"DAT-1604","status":"phase-1","modality":"Small molecule (oral tablet)","route":"/drugs/dat-1604/"},{"id":"moma-313","name":"MOMA-313","status":"phase-1","modality":"Small molecule (oral)","route":"/drugs/moma-313/"},{"id":"rp-3467","name":"RP-3467","status":"phase-1","modality":"Small molecule enzyme inhibitor","route":"/drugs/rp-3467/"}],"trials":[{"id":"nct06998173","name":"Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of DAT-1604 in Advanced Solid Tumor","nct":"NCT06998173","phase":"1","status":"planned"},{"id":"nct06560632","name":"Phase 1 Trial of RP-3467 Alone and in Combination With Olaparib in Participants With Advanced Solid Tumors","nct":"NCT06560632","phase":"1","status":"historic"},{"id":"nct06545942","name":"Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors","nct":"NCT06545942","phase":"1","status":"recruiting"}],"pathways":[],"companies":["danatlas-pharmaceuticals","moma-therapeutics","repare-therapeutics"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}