{"id":"tert","name":"TERT","symbol":"TERT","route":"/targets/tert/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11730","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164362","uniprot":"https://www.uniprot.org/uniprotkb/O14746/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/O14746","open-targets":"https://platform.opentargets.org/target/ENSG00000164362","civic":"https://civicdb.org/genes/7015/summary","oncokb":"https://www.oncokb.org/gene/TERT","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TERT","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=TERT","depmap":"https://depmap.org/portal/gene/TERT?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000164362-TERT","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/7015","omim":"https://www.omim.org/entry/187270"}],"products":[{"id":"ateganosine","name":"Ateganosine (THIO)","status":"phase-3","modality":"small molecule (nucleoside analogue)","route":"/drugs/ateganosine/"},{"id":"cbx-663","name":"CBX-663","status":"phase-1","modality":"TCR-mimetic T cell engager (T-Bolt)","route":"/drugs/cbx-663/"}],"trials":[{"id":"nct06908304","name":"A Phase III Study With THIO + Cemiplimab vs Chemotherapy as 3rd Line Treatment in Advanced/Metastatic NSCLC","nct":"NCT06908304","phase":"3","status":"recruiting"},{"id":"nct05208944","name":"THIO Sequenced With Cemiplimab in Advanced NSCLC","nct":"NCT05208944","phase":"2","status":"active"},{"id":"nct07779798","name":"A Phase 1, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Clinical Activity of CBX-663 in Participants With Relapsed or Refractory Myeloid Malignancies, Advanced Solid Tumors, or Recurrent or Progressive Glioblastoma.","nct":"NCT07779798","phase":"1","status":"recruiting"}],"pathways":[],"companies":["crossbow-therapeutics","maia-biotechnology"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}