{"entity":{"id":"1964","kind":"year","name":"1964 in oncology","aka":["1964"],"tldr":"Everything OnCo dates to 1964: 15 entries, 7 landmarks, 4 technologies, 2 approvals and 1 law or regulation. Each line links to the record it was read from, so the year is a view of the corpus rather than a second copy of it.","summary":"15 dated entries in OnCo fall in 1964: 7 landmarks, 4 technologies, 2 approvals, 1 law or regulation and 1 paper.\n\nOf those, 15 to the year only. Most of the corpus dates a fact to the year, because that is what the source it was read from gives; regulatory events and the readout calendar are the parts that carry a full date.\n\nEverything on this page is generated from the other records. It holds no fact of its own, and it changes when they do.","asOf":"2026-09-25","links":[],"tags":[],"related":["1963","1965"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Generated from every dated field in the corpus, not written by hand. The groups and the fields behind them are listed in src/lib/year-groups.ts; the reader is src/lib/years.ts."],"year":1964,"events":[{"group":"approval","date":"1964","precision":"year","title":"Dactinomycin (actinomycin D) approved in US","note":"Wilms tumour, rhabdomyosarcoma, Ewing sarcoma, gestational trophoblastic neoplasia, metastatic testicular cancer, regional perfusion for sarcoma","from":"dactinomycin","refs":[]},{"group":"approval","date":"1964","precision":"year","title":"Melphalan (including hepatic delivery system) approved in US","note":"Multiple myeloma; non-resectable epithelial ovarian carcinoma","from":"melphalan","refs":[]},{"group":"history","date":"1964","precision":"year","title":"Actinomycin D established as a second single agent","note":"Low-risk gestational trophoblastic neoplasia (FIGO score 0 to 6)","from":"low-risk-gtn","refs":["dactinomycin"]},{"group":"history","date":"1964","precision":"year","title":"Epstein-Barr virus discovered in Burkitt lymphoma cells","note":"Burkitt lymphoma. Epstein, Achong and Barr identify the first human tumour virus.","from":"burkitt-lymphoma","refs":[]},{"group":"history","date":"1964","precision":"year","title":"Hepatitis B surface antigen discovered (Blumberg)","note":"Hepatocellular carcinoma. Nobel Prize 1976; leads to the vaccine.","from":"hcc","refs":["hbv-hcv"]},{"group":"history","date":"1964","precision":"year","title":"MOPP chemotherapy cures advanced Hodgkin lymphoma at the NCI","note":"Advanced-stage classical Hodgkin lymphoma (stage III to IV)","from":"advanced-stage-classical-hodgkin-lymphoma","refs":["cytotoxic-chemotherapy"]},{"group":"history","date":"1964","precision":"year","title":"MOPP: first combination chemotherapy cure","note":"Hodgkin lymphoma","from":"hodgkin-lymphoma","refs":[]},{"group":"history","date":"1964","precision":"year","title":"MOPP: the first combination chemotherapy to cure an advanced cancer (DeVita, NCI)","note":"Hodgkin lymphoma","from":"hodgkin-lymphoma","refs":["cytotoxic-chemotherapy"]},{"group":"history","date":"1964","precision":"year","title":"O'Brien and Stout describe malignant fibrous histiocytoma","note":"Undifferentiated pleomorphic sarcoma (UPS)","from":"undifferentiated-pleomorphic-sarcoma","refs":[]},{"group":"law","date":"1964","precision":"year","title":"Declaration of Helsinki","note":"International, declaration.","from":"declaration-of-helsinki","refs":[]},{"group":"paper","date":"1964","precision":"year","title":"DYNAMICS OF TUMOR GROWTH","note":"LAIRD AK. British Journal of Cancer.","from":"paper-laird-br-j-cancer","refs":[]},{"group":"technology","date":"1964","precision":"year","title":"Gompertzian tumour growth","note":"First use in humans or first approval, as the technology record states it.","from":"gompertzian-growth-model","refs":[]},{"group":"technology","date":"1964","precision":"year","title":"Log-kill hypothesis (Skipper)","note":"First use in humans or first approval, as the technology record states it.","from":"log-kill-hypothesis","refs":[]},{"group":"technology","date":"1964","precision":"year","title":"Mathematical models of cancer (mathematical oncology)","note":"First use in humans or first approval, as the technology record states it.","from":"mathematical-oncology","refs":[]},{"group":"technology","date":"1964","precision":"year","title":"Remote afterloaders for HDR brachytherapy","note":"First use in humans or first approval, as the technology record states it.","from":"brachytherapy-afterloaders","refs":[]}]},"route":"/years/1964/","neighbours":{"year":[{"id":"1963","kind":"year","name":"1963 in oncology","route":"/years/1963/"},{"id":"1965","kind":"year","name":"1965 in oncology","route":"/years/1965/"}]}}