{"entity":{"id":"1971","kind":"year","name":"1971 in oncology","aka":["1971"],"tldr":"Everything OnCo dates to 1971: 14 entries, 7 landmarks, 2 approvals, 2 papers and 1 company founded. Each line links to the record it was read from, so the year is a view of the corpus rather than a second copy of it.","summary":"14 dated entries in OnCo fall in 1971: 7 landmarks, 2 approvals, 2 papers, 1 company founded, 1 journal founded and 1 technology.\n\nOf those, 14 to the year only. Most of the corpus dates a fact to the year, because that is what the source it was read from gives; regulatory events and the readout calendar are the parts that carry a full date.\n\nEverything on this page is generated from the other records. It holds no fact of its own, and it changes when they do.","asOf":"2026-09-25","links":[],"tags":[],"related":["1970","1972"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Generated from every dated field in the corpus, not written by hand. The groups and the fields behind them are listed in src/lib/year-groups.ts; the reader is src/lib/years.ts."],"year":1971,"events":[{"group":"approval","date":"1971","precision":"year","title":"Megestrol acetate approved in US","note":"Palliative treatment of advanced carcinoma of the breast or endometrium","from":"megestrol","refs":[]},{"group":"approval","date":"1971","precision":"year","title":"Progestins (megestrol acetate, medroxyprogesterone, levonorgestrel IUD) approved in US","note":"Palliative treatment of advanced endometrial and breast cancer (megestrol)","from":"megestrol-progestins","refs":[]},{"group":"company","date":"1971","precision":"year","title":"IRE (Institut national des Radioéléments) founded","note":"Fleurus","from":"ire","refs":[]},{"group":"history","date":"1971","precision":"year","title":"DES linked to vaginal clear cell adenocarcinoma","note":"Vaginal cancer. Herbst and colleagues (NEJM 1971) report the association; DES is withdrawn for pregnancy the same year.","from":"vaginal","refs":[]},{"group":"history","date":"1971","precision":"year","title":"Evans staging of neuroblastoma introduced; stage IV-S recognised as regressing disease","note":"Low-risk neuroblastoma (INRG very low and low risk, including stage MS)","from":"neuroblastoma-low-risk","refs":[]},{"group":"history","date":"1971","precision":"year","title":"Herbst links vaginal clear cell adenocarcinoma in young women to prenatal DES exposure; the FDA advises against DES in pregnancy","note":"Vaginal adenocarcinoma (including DES-associated clear cell adenocarcinoma)","from":"vaginal-adenocarcinoma","refs":[]},{"group":"history","date":"1971","precision":"year","title":"Knudson's two-hit hypothesis","note":"Retinoblastoma. Statistical analysis of hereditary vs sporadic retinoblastoma predicts tumour-suppressor genes.","from":"retinoblastoma","refs":[]},{"group":"history","date":"1971","precision":"year","title":"Progestins approved for advanced endometrial cancer","note":"Endometrial cancer","from":"endometrial","refs":["megestrol-progestins"]},{"group":"history","date":"1971","precision":"year","title":"Progestins approved for advanced endometrial cancer","note":"Advanced or recurrent endometrial cancer","from":"advanced-recurrent-endometrial-cancer","refs":["megestrol-progestins"]},{"group":"history","date":"1971","precision":"year","title":"Spontaneous regression of stage IV-S (now MS) disease recognised (Evans staging)","note":"Neuroblastoma (paediatric)","from":"neuroblastoma","refs":["inrg-staging"]},{"group":"journal","date":"1971","precision":"year","title":"Japanese journal of clinical oncology founded","note":"Oxford University Press","from":"japanese-journal-of-clinical-oncology","refs":[]},{"group":"paper","date":"1971","precision":"year","title":"Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumour appearance in young women","note":"Herbst AL, Ulfelder H, Poskanzer DC. New England Journal of Medicine.","from":"paper-herbst-diethylstilbestrol-vaginal-adenocarcinoma-nejm-1971","refs":[]},{"group":"paper","date":"1971","precision":"year","title":"Mutation and cancer: statistical study of retinoblastoma","note":"Knudson AG. Proceedings of the National Academy of Sciences.","from":"paper-knudson-proc-natl-acad-sci-u-s-a","refs":[]},{"group":"technology","date":"1971","precision":"year","title":"CT (computed tomography)","note":"First use in humans or first approval, as the technology record states it.","from":"ct","refs":[]}]},"route":"/years/1971/","neighbours":{"year":[{"id":"1970","kind":"year","name":"1970 in oncology","route":"/years/1970/"},{"id":"1972","kind":"year","name":"1972 in oncology","route":"/years/1972/"}]}}