{"entity":{"id":"1976","kind":"year","name":"1976 in oncology","aka":["1976"],"tldr":"Everything OnCo dates to 1976: 22 entries, 11 landmarks, 3 companies founded, 3 papers and 3 technologies. Each line links to the record it was read from, so the year is a view of the corpus rather than a second copy of it.","summary":"22 dated entries in OnCo fall in 1976: 11 landmarks, 3 companies founded, 3 papers, 3 technologies, 1 approval and 1 journal founded.\n\nOf those, 22 to the year only. Most of the corpus dates a fact to the year, because that is what the source it was read from gives; regulatory events and the readout calendar are the parts that carry a full date.\n\nEverything on this page is generated from the other records. It holds no fact of its own, and it changes when they do.","asOf":"2026-09-25","links":[],"tags":[],"related":["1975","1977"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Generated from every dated field in the corpus, not written by hand. The groups and the fields behind them are listed in src/lib/year-groups.ts; the reader is src/lib/years.ts."],"year":1976,"events":[{"group":"approval","date":"1976","precision":"year","title":"Lomustine (CCNU) approved in US","note":"Brain tumours after surgery/radiation; Hodgkin lymphoma","from":"lomustine","refs":[]},{"group":"company","date":"1976","precision":"year","title":"AIO (Arbeitsgemeinschaft Internistische Onkologie) founded","note":"Berlin","from":"aio","refs":[]},{"group":"company","date":"1976","precision":"year","title":"DAHANCA founded","note":"Denmark (seat not stated)","from":"dahanca","refs":[]},{"group":"company","date":"1976","precision":"year","title":"Danish Breast Cancer Group founded","note":"Copenhagen","from":"dbcg","refs":[]},{"group":"history","date":"1976","precision":"year","title":"Bagshawe develops the first prognostic scoring system at Charing Cross","note":"High-risk gestational trophoblastic neoplasia (FIGO score 7 or more, including ultra-high-risk)","from":"high-risk-gtn","refs":["staging-systems"]},{"group":"history","date":"1976","precision":"year","title":"BCG immunotherapy for bladder cancer","note":"Bladder & urothelial cancer","from":"urothelial","refs":[]},{"group":"history","date":"1976","precision":"year","title":"CHOP regimen introduced","note":"Diffuse large B-cell lymphoma. Cyclophosphamide, doxorubicin, vincristine, prednisone becomes the backbone for aggressive lymphoma.","from":"dlbcl","refs":["doxorubicin","cytotoxic-chemotherapy"]},{"group":"history","date":"1976","precision":"year","title":"Cisplatin transforms ovarian cancer chemotherapy","note":"Ovarian cancer. First platinum responses in refractory disease; carboplatin follows in the 1980s.","from":"ovarian","refs":[]},{"group":"history","date":"1976","precision":"year","title":"Kadish staging system published","note":"Esthesioneuroblastoma (olfactory neuroblastoma)","from":"esthesioneuroblastoma","refs":["staging-systems"]},{"group":"history","date":"1976","precision":"year","title":"Kurman, Scully and Norris describe placental-site trophoblastic tumour","note":"Placental-site trophoblastic tumour and epithelioid trophoblastic tumour","from":"placental-site-trophoblastic-tumour","refs":[]},{"group":"history","date":"1976","precision":"year","title":"Morales reports intravesical BCG","note":"Non-muscle-invasive bladder cancer","from":"non-muscle-invasive-bladder-cancer","refs":["bcg-and-intravesical-therapy"]},{"group":"history","date":"1976","precision":"year","title":"Morales reports intravesical BCG for bladder cancer","note":"Bladder & urothelial cancer","from":"urothelial","refs":["bcg-intravesical"]},{"group":"history","date":"1976","precision":"year","title":"Nevin stages gallbladder cancer by depth of invasion","note":"Gallbladder cancer. Sixty-six cases and 399 from the literature; essentially all found incidentally at gallstone surgery.","from":"gallbladder","refs":["paper-nevin-gallbladder-carcinoma-staging-cancer-1976","tnm-staging"]},{"group":"history","date":"1976","precision":"year","title":"Reed describes acral lentiginous melanoma as a distinct subtype","note":"Acral melanoma","from":"acral-melanoma","refs":[]},{"group":"history","date":"1976","precision":"year","title":"Tamoxifen shown active in men","note":"Male breast cancer. Early case series establish tamoxifen as the endocrine backbone.","from":"male-breast-cancer","refs":["tamoxifen"]},{"group":"journal","date":"1976","precision":"year","title":"Current problems in cancer founded","note":"Elsevier","from":"current-problems-in-cancer","refs":[]},{"group":"paper","date":"1976","precision":"year","title":"Carcinoma of the gallbladder: staging, treatment, and prognosis","note":"Nevin JE, Moran TJ, Kay S, King R. Cancer.","from":"paper-nevin-gallbladder-carcinoma-staging-cancer-1976","refs":[]},{"group":"paper","date":"1976","precision":"year","title":"Kadish staging: olfactory neuroblastoma, a clinical analysis of 17 cases","note":"Kadish S, Goodman M, Wang CC. Cancer.","from":"paper-kadish-olfactory-neuroblastoma-staging-cancer-1976","refs":[]},{"group":"paper","date":"1976","precision":"year","title":"The clonal evolution of tumor cell populations","note":"Nowell PC. Science.","from":"paper-nowell-science","refs":[]},{"group":"technology","date":"1976","precision":"year","title":"BCG manufacturing and the bladder cancer BCG shortage","note":"First use in humans or first approval, as the technology record states it.","from":"bcg-vaccine-manufacturing","refs":[]},{"group":"technology","date":"1976","precision":"year","title":"Clonal evolution and branching models","note":"First use in humans or first approval, as the technology record states it.","from":"clonal-evolution-models","refs":[]},{"group":"technology","date":"1976","precision":"year","title":"Cyclotron isotope production (F-18, Ga-68, Cu-64, Zr-89, At-211)","note":"First use in humans or first approval, as the technology record states it.","from":"cyclotron-isotope-production","refs":[]}]},"route":"/years/1976/","neighbours":{"year":[{"id":"1975","kind":"year","name":"1975 in oncology","route":"/years/1975/"},{"id":"1977","kind":"year","name":"1977 in oncology","route":"/years/1977/"}]}}