{"entity":{"id":"1977","kind":"year","name":"1977 in oncology","aka":["1977"],"tldr":"Everything OnCo dates to 1977: 24 entries, 11 landmarks, 5 technologies, 3 companies founded and 2 approvals. Each line links to the record it was read from, so the year is a view of the corpus rather than a second copy of it.","summary":"24 dated entries in OnCo fall in 1977: 11 landmarks, 5 technologies, 3 companies founded, 2 approvals, 2 journals founded and 1 law or regulation.\n\nOf those, 24 to the year only. Most of the corpus dates a fact to the year, because that is what the source it was read from gives; regulatory events and the readout calendar are the parts that carry a full date.\n\nEverything on this page is generated from the other records. It holds no fact of its own, and it changes when they do.","asOf":"2026-09-25","links":[],"tags":[],"related":["1976","1978"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Generated from every dated field in the corpus, not written by hand. The groups and the fields behind them are listed in src/lib/year-groups.ts; the reader is src/lib/years.ts."],"year":1977,"events":[{"group":"approval","date":"1977","precision":"year","title":"Carmustine approved in US","note":"Brain tumours, multiple myeloma, relapsed Hodgkin and non-Hodgkin lymphoma (BiCNU)","from":"carmustine","refs":[]},{"group":"approval","date":"1977","precision":"year","title":"Tamoxifen approved in US","note":"Advanced breast cancer","from":"tamoxifen","refs":[]},{"group":"company","date":"1977","precision":"year","title":"Children's Cancer and Leukaemia Group founded","note":"Leicester","from":"cclg","refs":[]},{"group":"company","date":"1977","precision":"year","title":"Glenmark Pharmaceuticals (Ichnos Glenmark Innovation) founded","note":"Mumbai","from":"glenmark","refs":[]},{"group":"company","date":"1977","precision":"year","title":"Intas Pharmaceuticals (Accord Healthcare) founded","note":"Ahmedabad","from":"intas","refs":[]},{"group":"history","date":"1977","precision":"year","title":"Angervall, Kindblom and Merck describe myxofibrosarcoma","note":"Myxofibrosarcoma","from":"myxofibrosarcoma","refs":[]},{"group":"history","date":"1977","precision":"year","title":"Cisplatin combination chemotherapy cures metastatic disease (Einhorn)","note":"Non-seminomatous germ cell tumour","from":"non-seminoma","refs":["cisplatin"]},{"group":"history","date":"1977","precision":"year","title":"Cisplatin combinations cure disseminated germ cell tumours","note":"Extragonadal germ cell tumour. Einhorn's PVB regimen (cisplatin, vinblastine, bleomycin) turned a usually fatal cancer into a curable one.","from":"extragonadal-germ-cell-tumour","refs":["cisplatin","vinblastine","bleomycin"]},{"group":"history","date":"1977","precision":"year","title":"Cisplatin combinations cure disseminated germ cell tumours","note":"Germ cell tumours of childhood and adolescence (extracranial and CNS). Einhorn's PVB regimen in testicular cancer, later adapted to children.","from":"paediatric-germ-cell-tumours","refs":["cisplatin"]},{"group":"history","date":"1977","precision":"year","title":"Einhorn's cisplatin combination cures metastatic germ cell tumours","note":"Seminoma","from":"seminoma","refs":["cisplatin"]},{"group":"history","date":"1977","precision":"year","title":"First allogeneic transplants cure refractory leukaemia","note":"Acute myeloid leukaemia. Thomas (Seattle) reports long-term survival after HLA-matched sibling transplant; Nobel Prize 1990.","from":"aml","refs":["allogeneic-hsct"]},{"group":"history","date":"1977","precision":"year","title":"Horie coins the term pancreatoblastoma for the childhood tumour with squamoid nests","note":"Pancreatoblastoma","from":"pancreatoblastoma","refs":["tumour-grade"]},{"group":"history","date":"1977","precision":"year","title":"Small-cell carcinoma of the prostate first described","note":"Neuroendocrine and small-cell prostate cancer","from":"prostate-nepc","refs":["sclc"]},{"group":"history","date":"1977","precision":"year","title":"t(15;17) translocation identified","note":"Acute promyelocytic leukaemia","from":"apl","refs":["cytogenetics"]},{"group":"history","date":"1977","precision":"year","title":"Tamoxifen approved","note":"HR-positive / HER2-negative breast cancer. The first targeted cancer drug; later shown to reduce mortality by a third over 15 years.","from":"breast-hr-positive","refs":["tamoxifen"]},{"group":"history","date":"1977","precision":"year","title":"Tamoxifen approved","note":"High-risk early HR-positive breast cancer","from":"hr-positive-early-high-risk","refs":["tamoxifen"]},{"group":"journal","date":"1977","precision":"year","title":"Leukemia research founded","note":"Elsevier","from":"leukemia-research","refs":[]},{"group":"journal","date":"1977","precision":"year","title":"Oncology nursing forum founded","note":"Oncology Nursing Society","from":"oncology-nursing-forum","refs":[]},{"group":"law","date":"1977","precision":"year","title":"WHO Essential Medicines List for cancer","note":"International, guidance.","from":"who-essential-medicines","refs":[]},{"group":"technology","date":"1977","precision":"year","title":"Endocrine therapy (SERMs, AIs, SERDs)","note":"First use in humans or first approval, as the technology record states it.","from":"endocrine-therapy","refs":[]},{"group":"technology","date":"1977","precision":"year","title":"MRI","note":"First use in humans or first approval, as the technology record states it.","from":"mri","refs":[]},{"group":"technology","date":"1977","precision":"year","title":"Norton-Simon hypothesis and dose-dense chemotherapy","note":"First use in humans or first approval, as the technology record states it.","from":"norton-simon-hypothesis","refs":[]},{"group":"technology","date":"1977","precision":"year","title":"PSK (Krestin) mushroom polysaccharide as adjuvant therapy","note":"First use in humans or first approval, as the technology record states it.","from":"psk-krestin-adjuvant","refs":[]},{"group":"technology","date":"1977","precision":"year","title":"Psycho-oncology and distress screening","note":"First use in humans or first approval, as the technology record states it.","from":"psycho-oncology","refs":[]}]},"route":"/years/1977/","neighbours":{"year":[{"id":"1976","kind":"year","name":"1976 in oncology","route":"/years/1976/"},{"id":"1978","kind":"year","name":"1978 in oncology","route":"/years/1978/"}]}}