{"entity":{"id":"1983","kind":"year","name":"1983 in oncology","aka":["1983"],"tldr":"Everything OnCo dates to 1983: 26 entries, 9 landmarks, 9 journals founded, 2 approvals and 2 laws and regulations. Each line links to the record it was read from, so the year is a view of the corpus rather than a second copy of it.","summary":"26 dated entries in OnCo fall in 1983: 9 landmarks, 9 journals founded, 2 approvals, 2 laws and regulations, 1 company founded, 1 paper, 1 paper listed on a person's page and 1 technology.\n\nOf those, 26 to the year only. Most of the corpus dates a fact to the year, because that is what the source it was read from gives; regulatory events and the readout calendar are the parts that carry a full date.\n\nEverything on this page is generated from the other records. It holds no fact of its own, and it changes when they do.","asOf":"2026-09-25","links":[],"tags":[],"related":["1982","1984"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Generated from every dated field in the corpus, not written by hand. The groups and the fields behind them are listed in src/lib/year-groups.ts; the reader is src/lib/years.ts."],"year":1983,"events":[{"group":"approval","date":"1983","precision":"year","title":"Etoposide approved in US","note":"Refractory testicular tumours; small-cell lung cancer (1986)","from":"etoposide","refs":[]},{"group":"approval","date":"1983","precision":"year","title":"Platinum + etoposide (EP / CE) approved in US","note":"Etoposide approved for SCLC; platinum-etoposide became standard in the 1980s","from":"platinum-etoposide","refs":[]},{"group":"company","date":"1983","precision":"year","title":"Sun Pharmaceutical Industries founded","note":"Mumbai","from":"sun-pharma","refs":[]},{"group":"history","date":"1983","precision":"year","title":"Bokhman's type I / type II model","note":"Endometrial cancer. Oestrogen-driven low-grade versus non-hormonal high-grade tumours; superseded by molecular classes.","from":"endometrial","refs":[]},{"group":"history","date":"1983","precision":"year","title":"Bokhman's type I oestrogen-driven endometrial cancer, the ancestor of this class","note":"Endometrial cancer with no specific molecular profile","from":"endometrial-nsmp","refs":[]},{"group":"history","date":"1983","precision":"year","title":"Helicobacter pylori identified (Marshall and Warren)","note":"Gastric & gastro-oesophageal junction cancer. Later classified as a class I carcinogen (1994); eradication shown to reduce gastric cancer incidence.","from":"gastric","refs":["chemoprevention"]},{"group":"history","date":"1983","precision":"year","title":"High-dose melphalan with autologous marrow rescue (McElwain)","note":"Multiple myeloma","from":"multiple-myeloma","refs":["autologous-stem-cell-transplant"]},{"group":"history","date":"1983","precision":"year","title":"Isaacson and Wright describe MALT lymphoma","note":"Marginal zone lymphoma","from":"marginal-zone-lymphoma","refs":[]},{"group":"history","date":"1983","precision":"year","title":"Large gallstones linked to cancer","note":"Gallbladder cancer. Diehl's case-control study finds an odds ratio of 10.1 for stones of 3 cm or more.","from":"gallbladder","refs":[]},{"group":"history","date":"1983","precision":"year","title":"McElwain: high-dose melphalan produces remissions in myeloma","note":"Newly diagnosed multiple myeloma, transplant-eligible","from":"myeloma-transplant-eligible","refs":["melphalan"]},{"group":"history","date":"1983","precision":"year","title":"MYCN amplification linked to aggressive disease (Brodeur, Schwab)","note":"Neuroblastoma (paediatric)","from":"neuroblastoma","refs":["mycn-amplification"]},{"group":"history","date":"1983","precision":"year","title":"zur Hausen identifies HPV16 in cervical cancer","note":"Cervical cancer. HPV18 follows in 1984; Nobel Prize 2008.","from":"cervical","refs":["dkfz","hpv-vaccine"]},{"group":"journal","date":"1983","precision":"year","title":"Cancer investigation founded","note":"Taylor & Francis","from":"cancer-investigation","refs":[]},{"group":"journal","date":"1983","precision":"year","title":"Clinical & experimental metastasis founded","note":"Springer","from":"clinical-and-experimental-metastasis","refs":[]},{"group":"journal","date":"1983","precision":"year","title":"Critical reviews in oncology/hematology founded","note":"Elsevier","from":"critical-reviews-in-oncology-hematology","refs":[]},{"group":"journal","date":"1983","precision":"year","title":"Hematological oncology founded","note":"Wiley","from":"hematological-oncology","refs":[]},{"group":"journal","date":"1983","precision":"year","title":"Journal of Clinical Oncology founded","note":"American Society of Clinical Oncology","from":"jco","refs":[]},{"group":"journal","date":"1983","precision":"year","title":"Journal of neuro-oncology founded","note":"Springer Nature","from":"journal-of-neuro-oncology","refs":[]},{"group":"journal","date":"1983","precision":"year","title":"Journal of psychosocial oncology founded","note":"Routledge (Taylor & Francis)","from":"journal-of-psychosocial-oncology","refs":[]},{"group":"journal","date":"1983","precision":"year","title":"Nature Biotechnology founded","note":"Springer Nature","from":"nature-biotechnology","refs":[]},{"group":"journal","date":"1983","precision":"year","title":"Radiotherapy and Oncology founded","note":"Elsevier","from":"radiotherapy-and-oncology","refs":[]},{"group":"law","date":"1983","precision":"year","title":"Orphan Drug Act 1983","note":"United States, statute.","from":"orphan-drug-act","refs":[]},{"group":"law","date":"1983","precision":"year","title":"Orphan drug designation","note":"United States, guidance.","from":"orphan-designation","refs":[]},{"group":"paper","date":"1983","precision":"year","title":"Hypomethylation distinguishes genes of some human cancers from their normal counterparts","note":"Feinberg AP, Vogelstein B. Nature.","from":"paper-feinberg-nature","refs":[]},{"group":"person-paper","date":"1983","precision":"year","title":"Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen","note":"Proceedings of the National Academy of Sciences","from":"moshe-oren","refs":[]},{"group":"technology","date":"1983","precision":"year","title":"Autologous stem cell transplant (high-dose therapy)","note":"First use in humans or first approval, as the technology record states it.","from":"autologous-stem-cell-transplant","refs":[]}]},"route":"/years/1983/","neighbours":{"year":[{"id":"1982","kind":"year","name":"1982 in oncology","route":"/years/1982/"},{"id":"1984","kind":"year","name":"1984 in oncology","route":"/years/1984/"}]}}