{"entity":{"id":"1992","kind":"year","name":"1992 in oncology","aka":["1992"],"tldr":"Everything OnCo dates to 1992: 36 entries, 15 landmarks, 8 journals founded, 4 papers listed on people's pages and 3 approvals. Each line links to the record it was read from, so the year is a view of the corpus rather than a second copy of it.","summary":"36 dated entries in OnCo fall in 1992: 15 landmarks, 8 journals founded, 4 papers listed on people's pages, 3 approvals, 2 laws and regulations, 2 papers, 1 company founded and 1 regulatory event.\n\nOf those, 1 to the day and 35 to the year only. Most of the corpus dates a fact to the year, because that is what the source it was read from gives; regulatory events and the readout calendar are the parts that carry a full date.\n\nEverything on this page is generated from the other records. It holds no fact of its own, and it changes when they do.","asOf":"2026-09-25","links":[],"tags":[],"related":["1991","1993"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Generated from every dated field in the corpus, not written by hand. The groups and the fields behind them are listed in src/lib/year-groups.ts; the reader is src/lib/years.ts."],"year":1992,"events":[{"group":"approval","date":"1992","precision":"year","title":"Aldesleukin (high-dose IL-2) approved in US","note":"Metastatic renal cell carcinoma","from":"aldesleukin","refs":[]},{"group":"approval","date":"1992","precision":"year","title":"Paclitaxel / nab-paclitaxel approved in US","note":"Ovarian cancer (now broad)","from":"paclitaxel","refs":[]},{"group":"approval","date":"1992","precision":"year","title":"Teniposide approved in US","note":"Refractory childhood acute lymphoblastic leukaemia, in combination induction","from":"teniposide","refs":[]},{"group":"company","date":"1992","precision":"year","title":"Vion Pharmaceuticals founded","note":"New Haven, CT","from":"vion-pharmaceuticals","refs":[]},{"group":"history","date":"1992","precision":"year","title":"Bonetti and colleagues propose the perivascular epithelioid cell concept","note":"Perivascular epithelioid cell tumour (PEComa)","from":"pecoma","refs":[]},{"group":"history","date":"1992","precision":"year","title":"Cyclin D1 and t(11;14) define MCL","note":"Mantle cell lymphoma. Mantle cell lymphoma recognised as a distinct entity (REAL classification 1994).","from":"mantle-cell-lymphoma","refs":[]},{"group":"history","date":"1992","precision":"year","title":"Dulguerov and Calcaterra propose a TNM-based staging","note":"Esthesioneuroblastoma (olfactory neuroblastoma)","from":"esthesioneuroblastoma","refs":["staging-systems"]},{"group":"history","date":"1992","precision":"year","title":"Escalated BEACOPP developed by the German Hodgkin Study Group","note":"Hodgkin lymphoma","from":"hodgkin-lymphoma","refs":["gbg"]},{"group":"history","date":"1992","precision":"year","title":"EWSR1-FLI1 fusion cloned (Delattre, Nature)","note":"Ewing sarcoma","from":"ewing-sarcoma","refs":[]},{"group":"history","date":"1992","precision":"year","title":"High-dose IL-2 approved","note":"Renal cell carcinoma","from":"rcc","refs":[]},{"group":"history","date":"1992","precision":"year","title":"High-dose IL-2 approved: first immunotherapy for RCC, with rare cures","note":"Renal cell carcinoma","from":"rcc","refs":["cytokine-therapy"]},{"group":"history","date":"1992","precision":"year","title":"High-dose interleukin-2 produces rare durable cures","note":"Melanoma. The first evidence that the immune system alone could eradicate metastatic melanoma.","from":"melanoma","refs":["cytokine-therapy"]},{"group":"history","date":"1992","precision":"year","title":"Klimstra and colleagues define the clinicopathological features of acinar cell carcinoma","note":"Pancreatic acinar cell carcinoma","from":"pancreatic-acinar-cell-carcinoma","refs":["tumour-grade"]},{"group":"history","date":"1992","precision":"year","title":"Meta-analysis: adding thoracic radiotherapy to chemotherapy improves survival in limited stage","note":"Limited-stage small-cell lung cancer","from":"limited-stage-sclc","refs":["chemoradiation","imrt-igrt"]},{"group":"history","date":"1992","precision":"year","title":"Meta-analysis: thoracic radiotherapy improves survival in limited-stage disease","note":"Small-cell lung cancer","from":"sclc","refs":["imrt-igrt"]},{"group":"history","date":"1992","precision":"year","title":"Methotrexate before radiotherapy doubles survival (DeAngelis)","note":"Primary CNS lymphoma","from":"primary-cns-lymphoma","refs":["methotrexate"]},{"group":"history","date":"1992","precision":"year","title":"Registry data define the lifetime risk in DES-exposed daughters at about one in a thousand","note":"Vaginal adenocarcinoma (including DES-associated clear cell adenocarcinoma)","from":"vaginal-adenocarcinoma","refs":[]},{"group":"history","date":"1992","precision":"year","title":"RTOG 85-01: chemoradiation beats radiotherapy alone","note":"Oesophageal squamous cell carcinoma","from":"oesophageal-squamous-cell-carcinoma","refs":[]},{"group":"history","date":"1992","precision":"year","title":"The Nottingham Prognostic Index is published","note":"Breast cancer (all types). Nine candidate factors were tested in 387 patients and three survived: size, node stage and grade.","from":"breast-cancer","refs":["nottingham-prognostic-index"]},{"group":"journal","date":"1992","precision":"year","title":"International journal of oncology founded","note":"Spandidos Publications","from":"international-journal-of-oncology","refs":[]},{"group":"journal","date":"1992","precision":"year","title":"Nature Genetics founded","note":"Springer Nature","from":"nature-genetics","refs":[]},{"group":"journal","date":"1992","precision":"year","title":"Oncology research founded","note":"Tech Science Press","from":"oncology-research","refs":[]},{"group":"journal","date":"1992","precision":"year","title":"Psycho-oncology founded","note":"Wiley","from":"psycho-oncology-journal","refs":[]},{"group":"journal","date":"1992","precision":"year","title":"Radiology and oncology founded","note":"Association of Radiology and Oncology (Ljubljana), on the Sciendo platform","from":"radiology-and-oncology","refs":[]},{"group":"journal","date":"1992","precision":"year","title":"Surgical oncology clinics of North America founded","note":"Elsevier","from":"surgical-oncology-clinics-of-north-america","refs":[]},{"group":"journal","date":"1992","precision":"year","title":"Surgical oncology founded","note":"Elsevier","from":"surgical-oncology","refs":[]},{"group":"journal","date":"1992","precision":"year","title":"The Breast founded","note":"Elsevier","from":"the-breast","refs":[]},{"group":"law","date":"1992","precision":"year","title":"340B Drug Pricing Program","note":"United States, statute.","from":"340b-program","refs":[]},{"group":"law","date":"1992","precision":"year","title":"Accelerated approval","note":"United States, regulation.","from":"accelerated-approval","refs":[]},{"group":"paper","date":"1992","precision":"year","title":"Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours","note":"Delattre O, Zucman J, Plougastel B, et al. Nature.","from":"paper-delattre-nature","refs":[]},{"group":"paper","date":"1992","precision":"year","title":"Klimstra 1992: acinar cell carcinoma of the pancreas, a clinicopathologic study of 28 cases","note":"Klimstra DS, Heffess CS, Oertel JE, Rosai J. American Journal of Surgical Pathology.","from":"paper-klimstra-acinar-cell-carcinoma-pancreas-28-cases-ajsp-1992","refs":[]},{"group":"person-paper","date":"1992","precision":"year","title":"ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex","note":"Nature","from":"bruce-stillman","refs":[]},{"group":"person-paper","date":"1992","precision":"year","title":"Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic","note":"PNAS","from":"douglas-lowy","refs":[]},{"group":"person-paper","date":"1992","precision":"year","title":"Relative risk trees for censored survival data","note":"Biometrics","from":"michael-leblanc","refs":[]},{"group":"person-paper","date":"1992","precision":"year","title":"Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones","note":"Science","from":"stanley-riddell","refs":[]},{"group":"regulatory","date":"1992-12-29","precision":"day","title":"Paclitaxel / nab-paclitaxel: approval (US)","note":"Refractory ovarian cancer","from":"paclitaxel","refs":[]}]},"route":"/years/1992/","neighbours":{"year":[{"id":"1991","kind":"year","name":"1991 in oncology","route":"/years/1991/"},{"id":"1993","kind":"year","name":"1993 in oncology","route":"/years/1993/"}]}}