{"entity":{"id":"abcc10","kind":"target","name":"ABCC10","aka":["ATP binding cassette subfamily C member 10","ATP-binding cassette sub-family C member 10","EST182763","MRP7","SIMRP7"],"tldr":"ABCC10 (ATP-binding cassette sub-family C member 10) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.","summary":"ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May regulate the transport of organic compounds in testes across the blood-testis-barrier.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:52","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:52"},{"label":"UniProt Q5T3U5","url":"https://www.uniprot.org/uniprotkb/Q5T3U5/entry"},{"label":"NCBI Gene 89845","url":"https://www.ncbi.nlm.nih.gov/gene/89845"},{"label":"Ensembl ENSG00000124574","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124574"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ABCC10","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:52","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:52","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q5T3U5","url":"https://www.uniprot.org/uniprotkb/Q5T3U5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ABCC10","url":"https://civicdb.org/features/16656","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:52","ensembl":"ENSG00000124574","uniprot":"Q5T3U5","entrez":"89845","biology":"ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May regulate the transport of organic compounds in testes across the blood-testis-barrier. Mediates intercellular propagation of antiviral immune signalling in early stages of infection. In RNA virus-infected cells, oligoadenylate synthase senses viral dsRNA and generates 2',5'-oligoadenylates (2-5A) which act as second messengers to activate RNASEL and type I interferon signalling to inhibit viral replication. This innate signalling pathway is locally extended and amplified by ABCC10, which exports 2-5A from virus-infected cells to cross-activates RNASEL in uninfected neighboring cells and confers protection against viral infection. Location: Cell membrane; Basolateral cell membrane; Basal cell membrane (UniProt). Locus 6p21.1 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/abcc10/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}