{"entity":{"id":"abcc3","kind":"target","name":"ABCC3","aka":["ATP binding cassette subfamily C member 3","ATP-binding cassette sub-family C member 3","MRP3","cMOAT2","EST90757","MLP2","MOAT-D"],"tldr":"ABCC3 (ATP-binding cassette sub-family C member 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.","summary":"ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at basolateral membranes of polarised cells such as hepatocytes and intestinal epithelial cells, where it mediates the efflux of conjugated substrates from intestine and liver into the bloodstream. Involved in enterohepatic recirculation of steroid glucuronates.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel and Monomethyl Auristatin E.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:54","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:54"},{"label":"UniProt O15438","url":"https://www.uniprot.org/uniprotkb/O15438/entry"},{"label":"NCBI Gene 8714","url":"https://www.ncbi.nlm.nih.gov/gene/8714"},{"label":"Ensembl ENSG00000108846","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108846"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ABCC3","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:54","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:54","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15438","url":"https://www.uniprot.org/uniprotkb/O15438/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ABCC3","url":"https://civicdb.org/features/6906","note":"1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:54","ensembl":"ENSG00000108846","uniprot":"O15438","entrez":"8714","biology":"ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at basolateral membranes of polarised cells such as hepatocytes and intestinal epithelial cells, where it mediates the efflux of conjugated substrates from intestine and liver into the bloodstream. Involved in enterohepatic recirculation of steroid glucuronates. Shares substrate specificity with MRP2, displaying higher affinity for both oestrogen and androgen glucuronates such as 17beta-estradiol, estrone, testosterone and 5alpha-dihydrotestosterone glucuronates. Involved in sinusoidal efflux of mono- and bis-glucuronidated bilirubin from hepatocytes into the blood for renal uptake and excretion. May selectively transport steroid sulfate conjugates. Location: Basolateral cell membrane; Basal cell membrane (UniProt). Locus 17q21.33 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/abcc3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}