{"entity":{"id":"abcc4","kind":"target","name":"ABCC4","aka":["ATP binding cassette subfamily C member 4 (PEL blood group)","ATP-binding cassette sub-family C member 4","MRP4","EST170205","MOAT-B","MOATB"],"tldr":"ABCC4 (ATP-binding cassette sub-family C member 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Angiosarcoma.","summary":"ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signalling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Angiosarcoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:55","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:55"},{"label":"UniProt O15439","url":"https://www.uniprot.org/uniprotkb/O15439/entry"},{"label":"NCBI Gene 10257","url":"https://www.ncbi.nlm.nih.gov/gene/10257"},{"label":"Ensembl ENSG00000125257","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125257"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["angiosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ABCC4","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:55","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:55","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15439","url":"https://www.uniprot.org/uniprotkb/O15439/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ABCC4","url":"https://www.intogen.org/search?gene=ABCC4","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:55","ensembl":"ENSG00000125257","uniprot":"O15439","entrez":"10257","biology":"ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signalling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). May contribute to hepatic, intestinal and renal excretion of steroid conjugates. Location: Basolateral cell membrane; Apical cell membrane (UniProt). Locus 13q32.1 (HGNC).","whereFound":["Angiosarcoma: IntOGen driver in 1 cohort (ANGS)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/abcc4/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"angiosarcoma","kind":"cancer","name":"Angiosarcoma","route":"/cancers/angiosarcoma/"}]}}