{"entity":{"id":"abi1","kind":"target","name":"ABI1","aka":["abl interactor 1","Abl interactor 1","E3B1","ABI-1","SSH3BP1"],"tldr":"ABI1 (Abl interactor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganisation and EGFR signalling.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11320","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11320"},{"label":"UniProt Q8IZP0","url":"https://www.uniprot.org/uniprotkb/Q8IZP0/entry"},{"label":"NCBI Gene 10006","url":"https://www.ncbi.nlm.nih.gov/gene/10006"},{"label":"Ensembl ENSG00000136754","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136754"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ABI1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11320","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11320","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IZP0","url":"https://www.uniprot.org/uniprotkb/Q8IZP0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000136754","url":"https://platform.opentargets.org/target/ENSG00000136754/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: breast cancer 0.56 (GraphQL API, CC0)"}],"hgnc":"HGNC:11320","ensembl":"ENSG00000136754","uniprot":"Q8IZP0","entrez":"10006","biology":"May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganisation and EGFR signalling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Location: Cytoplasm; Nucleus; Cell projection, lamellipodium; Cell projection, filopodium (UniProt). Locus 10p12.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)"],"targetClass":"other","prevalence":[]},"route":"/targets/abi1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}