{"entity":{"id":"abo","kind":"target","name":"ABO","aka":["ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase","Histo-blood group ABO system transferase","A3GALNT","A3GALT1"],"tldr":"ABO (Histo-blood group ABO system transferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.","summary":"This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of N-acetyl-alpha-D-galactosamine (GalNAc)) or to the B antigen (by addition of galactose (Gal)), whereas O individuals lack such activity and express the H antigen precursor unmodified.\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.85, genetic association 0.68).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:79","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:79"},{"label":"UniProt P16442","url":"https://www.uniprot.org/uniprotkb/P16442/entry"},{"label":"NCBI Gene 28","url":"https://www.ncbi.nlm.nih.gov/gene/28"},{"label":"Ensembl ENSG00000175164","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175164"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ABO","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:79","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:79","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P16442","url":"https://www.uniprot.org/uniprotkb/P16442/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000175164","url":"https://platform.opentargets.org/target/ENSG00000175164/associations","note":"association with cancer (MONDO_0004992) 0.55;  (GraphQL API, CC0)"}],"hgnc":"HGNC:79","ensembl":"ENSG00000175164","uniprot":"P16442","entrez":"28","biology":"This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of N-acetyl-alpha-D-galactosamine (GalNAc)) or to the B antigen (by addition of galactose (Gal)), whereas O individuals lack such activity and express the H antigen precursor unmodified. Catalyses the transfer of GalNAc or Gal in an alpha1,3 linkage to the terminal Gal of all five types of naturally occurring H antigens, forming the antigenic structures of the A and B blood groups. Location: Golgi apparatus, Golgi stack membrane; Secreted (UniProt). Locus 9q34.2 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/abo/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}