{"entity":{"id":"achieve-life-sciences","kind":"company","name":"Achieve Life Sciences (formerly OncoGenex)","aka":["Achieve Life Sciences, Inc.","OncoGenex Pharmaceuticals","OncoGenex"],"tldr":"Achieve Life Sciences carries the trial record of OncoGenex, whose antisense drug custirsen failed phase 3 trials in prostate and lung cancer before the company turned to a smoking-cessation medicine.","summary":"OncoGenex Pharmaceuticals, founded in 2000 in Bothell, Washington, developed custirsen (OGX-011), an antisense inhibitor of clusterin, and led the phase 3 SYNERGY and AFFINITY trials in metastatic castration-resistant prostate cancer and a phase 3 trial in non-small cell lung cancer, none of which improved survival. In 2017 it merged with Achieve Life Sciences, which now develops cytisinicline for smoking cessation, a cancer prevention aim. The custirsen trials sit on ClinicalTrials.gov under the Achieve name.","asOf":"2026-09-11","links":[{"label":"Official website","url":"https://www.achievelifesciences.com"},{"label":"ClinicalTrials.gov: trials led by Achieve Life Sciences, Inc.","url":"https://clinicaltrials.gov/search?lead=Achieve%20Life%20Sciences%2C%20Inc."},{"label":"Wikidata","url":"https://www.wikidata.org/wiki/Q30269222"}],"tags":["ctgov-sponsor"],"related":[],"cancers":["prostate","nsclc"],"sections":["prevention"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"Bothell, WA","country":"US","companyType":"biotech","website":"https://www.achievelifesciences.com","founded":2000,"stage":"public","investors":[],"funding":[]},"route":"/companies/achieve-life-sciences/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"section":[{"id":"prevention","kind":"section","name":"Prevention & Risk","route":"/fronts/prevention/"}]}}