{"entity":{"id":"acr-6840","kind":"drug","name":"ACR-6840","aka":[],"tldr":"ACR-6840 is an experimental small molecule from Acrivon Therapeutics, in preclinical development for cancer.","summary":"ACR-6840 is a small molecule from Acrivon Therapeutics. An inhibitor of CDK11 from Acrivon's AP3-driven cell-cycle programme. Its furthest stage is preclinical development, for cancer. No clinical trial naming it is registered on ClinicalTrials.gov. IND-enabling studies; IND filing for ACR-6840 'or alternative CDK11 inhibitor candidate' planned for the first half of 2027 (Q1 2026 results release, 13 May 2026). The 12 August 2026 release no longer names ACR-6840 and refers to an 'Internally-discovered development candidate'. It has not been shown to work in people.","status":"preclinical","asOf":"2026-11-03","links":[{"label":"Acrivon Therapeutics: sec.gov","url":"https://www.sec.gov/Archives/edgar/data/1781174/000119312526221626/acrv-ex99_1.htm"},{"label":"Acrivon Therapeutics: sec.gov","url":"https://www.sec.gov/Archives/edgar/data/1781174/000119312526221626/acrv-ex99_1.htm"},{"label":"Acrivon Therapeutics: sec.gov","url":"https://www.sec.gov/Archives/edgar/data/1781174/000119312526346859/acrv-ex99_1.htm"}],"tags":["pipeline"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":["cdk11"],"drugs":[],"companies":["acrivon-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"ACR-6840","modality":"Small molecule","mechanism":"An inhibitor of CDK11 from Acrivon's AP3-driven cell-cycle programme.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/acr-6840/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"target":[{"id":"cdk11","kind":"target","name":"CDK11","route":"/targets/cdk11/"}],"company":[{"id":"acrivon-therapeutics","kind":"company","name":"Acrivon Therapeutics","route":"/companies/acrivon-therapeutics/"}]}}