{"entity":{"id":"acsl6","kind":"target","name":"ACSL6","aka":["acyl-CoA synthetase long chain family member 6","Long-chain-fatty-acid--CoA ligase 6","KIAA0837","ACS2","LACS5","LACS2","FACL6"],"tldr":"ACSL6 (Long-chain-fatty-acid--CoA ligase 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Liposarcoma.","summary":"Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilised exclusively for the synthesis of the brain lipid.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Liposarcoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16496","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16496"},{"label":"UniProt Q9UKU0","url":"https://www.uniprot.org/uniprotkb/Q9UKU0/entry"},{"label":"NCBI Gene 23305","url":"https://www.ncbi.nlm.nih.gov/gene/23305"},{"label":"Ensembl ENSG00000164398","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164398"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["sarcoma","liposarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ACSL6","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:16496","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16496","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UKU0","url":"https://www.uniprot.org/uniprotkb/Q9UKU0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ACSL6","url":"https://www.intogen.org/search?gene=ACSL6","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:16496","ensembl":"ENSG00000164398","uniprot":"Q9UKU0","entrez":"23305","biology":"Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilised exclusively for the synthesis of the brain lipid. Location: Mitochondrion outer membrane; Peroxisome membrane; Microsome membrane; Endoplasmic reticulum membrane (UniProt). Locus 5q31.1 (HGNC).","whereFound":["Sarcomas: IntOGen driver in 1 cohort (LIPO)","Liposarcoma: IntOGen driver in 1 cohort (LIPO)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/acsl6/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"liposarcoma","kind":"cancer","name":"Liposarcoma","route":"/cancers/liposarcoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}