{"entity":{"id":"acsm3","kind":"target","name":"ACSM3","aka":["acyl-CoA synthetase medium chain family member 3","Acyl-coenzyme A synthetase ACSM3, mitochondrial"],"tldr":"ACSM3 (Acyl-coenzyme A synthetase ACSM3, mitochondrial) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.","summary":"Catalyses the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Glioblastoma Multiforme.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10522","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10522"},{"label":"UniProt Q53FZ2","url":"https://www.uniprot.org/uniprotkb/Q53FZ2/entry"},{"label":"NCBI Gene 6296","url":"https://www.ncbi.nlm.nih.gov/gene/6296"},{"label":"Ensembl ENSG00000005187","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000005187"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ACSM3","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:10522","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10522","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q53FZ2","url":"https://www.uniprot.org/uniprotkb/Q53FZ2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ACSM3","url":"https://www.intogen.org/search?gene=ACSM3","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:10522","ensembl":"ENSG00000005187","uniprot":"Q53FZ2","entrez":"6296","biology":"Catalyses the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms. Location: Mitochondrion; Mitochondrion matrix (UniProt). Locus 16p12.3 (HGNC).","whereFound":["Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/acsm3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}]}}