{"entity":{"id":"acta1","kind":"target","name":"ACTA1","aka":["actin alpha 1, skeletal muscle","Actin, alpha skeletal muscle","NEM3"],"tldr":"ACTA1 (Actin, alpha skeletal muscle) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.","summary":"Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:129","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:129"},{"label":"UniProt P68133","url":"https://www.uniprot.org/uniprotkb/P68133/entry"},{"label":"NCBI Gene 58","url":"https://www.ncbi.nlm.nih.gov/gene/58"},{"label":"Ensembl ENSG00000143632","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143632"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ACTA1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:129","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:129","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P68133","url":"https://www.uniprot.org/uniprotkb/P68133/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ACTA1","url":"https://civicdb.org/features/128","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:129","ensembl":"ENSG00000143632","uniprot":"P68133","entrez":"58","biology":"Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1q42.13 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/acta1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}