{"entity":{"id":"actb","kind":"target","name":"ACTB","aka":["actin beta","Actin, cytoplasmic 1"],"tldr":"ACTB (Actin, cytoplasmic 1) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Actin is a highly conserved protein that polymerises to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localise in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.97, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:132","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:132"},{"label":"UniProt P60709","url":"https://www.uniprot.org/uniprotkb/P60709/entry"},{"label":"NCBI Gene 60","url":"https://www.ncbi.nlm.nih.gov/gene/60"},{"label":"Ensembl ENSG00000075624","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000075624"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ACTB","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:132","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:132","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P60709","url":"https://www.uniprot.org/uniprotkb/P60709/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ACTB","url":"https://civicdb.org/features/130","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000075624","url":"https://platform.opentargets.org/target/ENSG00000075624/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:132","ensembl":"ENSG00000075624","uniprot":"P60709","entrez":"60","biology":"Actin is a highly conserved protein that polymerises to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localise in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. Location: Cytoplasm, cytoskeleton; Nucleus (UniProt). Locus 7p22.1 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/actb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}