{"entity":{"id":"actg1","kind":"target","name":"ACTG1","aka":["actin gamma 1","Actin, cytoplasmic 2","DFNA20","DFNA26"],"tldr":"ACTG1 (Actin, cytoplasmic 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.97, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:144","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:144"},{"label":"UniProt P63261","url":"https://www.uniprot.org/uniprotkb/P63261/entry"},{"label":"NCBI Gene 71","url":"https://www.ncbi.nlm.nih.gov/gene/71"},{"label":"Ensembl ENSG00000184009","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184009"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ACTG1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:144","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:144","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P63261","url":"https://www.uniprot.org/uniprotkb/P63261/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000184009","url":"https://platform.opentargets.org/target/ENSG00000184009/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:144","ensembl":"ENSG00000184009","uniprot":"P63261","entrez":"71","biology":"Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage. Location: Cytoplasm, cytoskeleton (UniProt). Locus 17q25.3 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/actg1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}