{"entity":{"id":"actl6a","kind":"target","name":"ACTL6A","aka":["actin like 6A","Actin-like protein 6A","Actl6","BAF53A","Arp4","Baf53a","INO80K","SMARCN1"],"tldr":"ACTL6A (Actin-like protein 6A) is a protein that switches other genes on and off. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer and Non-small-cell lung cancer.","summary":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix.\n\nCIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin and Panobinostat.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:24124","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24124"},{"label":"UniProt O96019","url":"https://www.uniprot.org/uniprotkb/O96019/entry"},{"label":"NCBI Gene 86","url":"https://www.ncbi.nlm.nih.gov/gene/86"},{"label":"Ensembl ENSG00000136518","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136518"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["ovarian","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants; UniProt keyword \"DNA repair\". Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ACTL6A","role":["drug-target","biomarker","dna-repair"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:24124","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24124","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O96019","url":"https://www.uniprot.org/uniprotkb/O96019/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ACTL6A","url":"https://civicdb.org/features/150","note":"3 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma, Ovarian Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:24124","ensembl":"ENSG00000136518","uniprot":"O96019","entrez":"86","biology":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. Location: Nucleus (UniProt). Locus 3q26.33 (HGNC).","whereFound":["Ovarian cancer: CIViC evidence names this disease","Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/actl6a/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}