{"entity":{"id":"acvr2a","kind":"target","name":"ACVR2A","aka":["activin A receptor type 2A","Activin receptor type-2A","ACTRII","ACVR2"],"tldr":"ACVR2A (Activin receptor type-2A) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Hepatocellular carcinoma, Pancreatic ductal adenocarcinoma and 4 more.","summary":"On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.\n\nOpen Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.92, animal model 0.27, genetic association 0.41, somatic mutation 0.94). IntOGen calls it a driver in 13 cohorts (1 activating, 12 loss-of-function), covering Colorectal Adenocarcinoma, Cutaneous Squamous Cell Carcinoma, Hepatocellular Carcinoma, Pancreatic Adenocarcinoma, Prostate Adenocarcinoma, Stomach Adenocarcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:173","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:173"},{"label":"UniProt P27037","url":"https://www.uniprot.org/uniprotkb/P27037/entry"},{"label":"NCBI Gene 92","url":"https://www.ncbi.nlm.nih.gov/gene/92"},{"label":"Ensembl ENSG00000121989","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000121989"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["colorectal","hcc","pancreatic","gastric","prostate","endometrial","cutaneous-scc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 12 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ACVR2A","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:173","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:173","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P27037","url":"https://www.uniprot.org/uniprotkb/P27037/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000121989","url":"https://platform.opentargets.org/target/ENSG00000121989/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.64, gastric cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen ACVR2A","url":"https://www.intogen.org/search?gene=ACVR2A","note":"driver in 13 cohorts (Act 1, LoF 12); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:173","ensembl":"ENSG00000121989","uniprot":"P27037","entrez":"92","biology":"On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. Location: Cell membrane (UniProt). Locus 2q22.3-q23.1 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.64 with colorectal cancer (MONDO_0005575); IntOGen driver in 3 cohorts (COADREAD)","Hepatocellular carcinoma: IntOGen driver in 3 cohorts (HCC)","Pancreatic ductal adenocarcinoma: IntOGen driver in 3 cohorts (PAAD)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.56 with gastric cancer (MONDO_0001056); IntOGen driver in 1 cohort (STAD)","Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Endometrial cancer: IntOGen driver in 1 cohort (UCEC)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/acvr2a/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"cutaneous-scc","kind":"cancer","name":"Cutaneous squamous cell carcinoma","route":"/cancers/cutaneous-scc/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}