{"entity":{"id":"adamts9","kind":"target","name":"ADAMTS9","aka":["ADAM metallopeptidase with thrombospondin type 1 motif 9","A disintegrin and metalloproteinase with thrombospondin motifs 9","KIAA1312"],"tldr":"ADAMTS9 (A disintegrin and metalloproteinase with thrombospondin motifs 9) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma.","summary":"Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). In addition, catalyses the shedding of the endopeptidase MMP14 (at the '314-Tyr-|-Gly-315' site), releasing the catalytic domain from the cell surface thereby preventing the downstream pro-MMP2 activation. Is involved in extracellular matrix proteolysis and in ciliary vesicle growth during ciliogenesis in metalloendopeptidase activity dependent manner.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.63, somatic mutation 0.33). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Plasma Cell Myeloma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13202","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13202"},{"label":"UniProt Q9P2N4","url":"https://www.uniprot.org/uniprotkb/Q9P2N4/entry"},{"label":"NCBI Gene 56999","url":"https://www.ncbi.nlm.nih.gov/gene/56999"},{"label":"Ensembl ENSG00000163638","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163638"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["multiple-myeloma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ADAMTS9","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:13202","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13202","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9P2N4","url":"https://www.uniprot.org/uniprotkb/Q9P2N4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000163638","url":"https://platform.opentargets.org/target/ENSG00000163638/associations","note":"association with cancer (MONDO_0004992) 0.54;  (GraphQL API, CC0)"},{"label":"IntOGen ADAMTS9","url":"https://www.intogen.org/search?gene=ADAMTS9","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:13202","ensembl":"ENSG00000163638","uniprot":"Q9P2N4","entrez":"56999","biology":"Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). In addition, catalyses the shedding of the endopeptidase MMP14 (at the '314-Tyr-|-Gly-315' site), releasing the catalytic domain from the cell surface thereby preventing the downstream pro-MMP2 activation. Is involved in extracellular matrix proteolysis and in ciliary vesicle growth during ciliogenesis in metalloendopeptidase activity dependent manner. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. Location: Secreted, extracellular space, extracellular matrix; Endoplasmic reticulum; Cell projection, cilium; Recycling endosome (UniProt). Locus 3p14.1 (HGNC).","whereFound":["Multiple myeloma: IntOGen driver in 1 cohort (PCM)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/adamts9/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}]}}