{"entity":{"id":"adept-star-net-1","kind":"drug","name":"ADEPT-STAR-NET-1","aka":["STAR-NET-1"],"tldr":"ADEPT-STAR-NET-1 is an experimental cell therapy from Expression Therapeutics for neuroendocrine tumours. It has not yet been tested in people.","summary":"ADEPT-STAR-NET-1 is Expression Therapeutics' lead cancer programme. The company reports that STAR-NET-1 gives unmodified gamma-delta T cells potent killing of SSTR2-positive cells in the femtomolar range and eradicated spheroids grown from gastroenteropancreatic neuroendocrine tumour samples in its laboratory model. No registered trial was found.","status":"preclinical","asOf":"2026-11-04","links":[{"label":"Expression Therapeutics: neuroendocrine tumours","url":"https://www.expressiontherapeutics.com/therapeutics-nets"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":[],"technologies":["gamma-delta-t-cell-therapy","t-cell-engager"],"targets":["sstr2"],"drugs":[],"companies":["expression-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors","editedOn":"2026-11-04"},"code":"STAR-NET-1","modality":"Engineered autologous gamma-delta T-cell therapy secreting a T-cell engager","mechanism":"Autologous gamma-delta T cells programmed with the LENTeT gene transfer system to secrete STAR-NET-1, a CD3 epsilon by SSTR2 bispecific T-cell engager, so that both the infused cells and the patient's own T cells attack SSTR2-bearing tumour cells, as described by Expression Therapeutics.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/adept-star-net-1/","neighbours":{"technology":[{"id":"gamma-delta-t-cell-therapy","kind":"technology","name":"Gamma-delta T cell therapy","route":"/technologies/gamma-delta-t-cell-therapy/"},{"id":"t-cell-engager","kind":"technology","name":"T-cell engagers (bispecific)","route":"/technologies/t-cell-engager/"}],"target":[{"id":"sstr2","kind":"target","name":"Somatostatin receptor 2","route":"/targets/sstr2/"}],"company":[{"id":"expression-therapeutics","kind":"company","name":"Expression Therapeutics","route":"/companies/expression-therapeutics/"}]}}