{"entity":{"id":"adh1b","kind":"target","name":"ADH1B","aka":["alcohol dehydrogenase 1B (class I), beta polypeptide","All-trans-retinol dehydrogenase [NAD(+)] ADH1B","ADH2"],"tldr":"ADH1B (All-trans-retinol dehydrogenase [NAD(+)] ADH1B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oesophageal cancer.","summary":"Catalyses the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyse the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyses in the oxidative direction with higher efficiency.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.74).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:250","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:250"},{"label":"UniProt P00325","url":"https://www.uniprot.org/uniprotkb/P00325/entry"},{"label":"NCBI Gene 125","url":"https://www.ncbi.nlm.nih.gov/gene/125"},{"label":"Ensembl ENSG00000196616","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196616"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["esophageal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ADH1B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:250","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:250","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P00325","url":"https://www.uniprot.org/uniprotkb/P00325/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000196616","url":"https://platform.opentargets.org/target/ENSG00000196616/associations","note":"association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: oesophageal cancer 0.56 (GraphQL API, CC0)"}],"hgnc":"HGNC:250","ensembl":"ENSG00000196616","uniprot":"P00325","entrez":"125","biology":"Catalyses the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyse the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyses in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. Location: Cytoplasm (UniProt). Locus 4q23 (HGNC).","whereFound":["Oesophageal cancer: Open Targets association 0.56 with oesophageal cancer (MONDO_0007576)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/adh1b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"}]}}