{"entity":{"id":"adra1b","kind":"target","name":"ADRA1B","aka":["adrenoceptor alpha 1B","Alpha-1B adrenergic receptor"],"tldr":"ADRA1B (Alpha-1B adrenergic receptor) is a receptor that reads hormone signals inside the cell nucleus. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.","summary":"Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1B binds the catecholamine ligands norepinephrine and epinephrine.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.74, animal model 0.52, genetic association 0.05, clinical 0.86).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:278","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:278"},{"label":"UniProt P35368","url":"https://www.uniprot.org/uniprotkb/P35368/entry"},{"label":"NCBI Gene 147","url":"https://www.ncbi.nlm.nih.gov/gene/147"},{"label":"Ensembl ENSG00000170214","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000170214"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ADRA1B","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:278","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:278","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35368","url":"https://www.uniprot.org/uniprotkb/P35368/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000170214","url":"https://platform.opentargets.org/target/ENSG00000170214/associations","note":"association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:278","ensembl":"ENSG00000170214","uniprot":"P35368","entrez":"147","biology":"Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1B binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) and G(16) proteins. Nuclear ADRA1B forms heterooligomers with ADRA1A to regulate phenylephrine(PE)-stimulated ERK signalling in cardiac myocytes. At the plasma membrane, ADRA1B interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy. Location: Nucleus membrane; Cell membrane; Cytoplasm; Membrane, caveola (UniProt). Locus 5q33.3 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.52 with neuroendocrine neoplasm (MONDO_0019496)"],"targetClass":"nuclear-receptor","prevalence":[]},"route":"/targets/adra1b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}]}}