{"entity":{"id":"adra2b","kind":"target","name":"ADRA2B","aka":["adrenoceptor alpha 2B","Alpha-2B adrenergic receptor","ADRARL1","ADRA2L1","ADRA2RL1"],"tldr":"ADRA2B (Alpha-2B adrenergic receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.11, animal model 0.43, clinical 0.81).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:282","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:282"},{"label":"UniProt P18089","url":"https://www.uniprot.org/uniprotkb/P18089/entry"},{"label":"NCBI Gene 151","url":"https://www.ncbi.nlm.nih.gov/gene/151"},{"label":"Ensembl ENSG00000274286","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000274286"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.81. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ADRA2B","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:282","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:282","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P18089","url":"https://www.uniprot.org/uniprotkb/P18089/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000274286","url":"https://platform.opentargets.org/target/ENSG00000274286/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:282","ensembl":"ENSG00000274286","uniprot":"P18089","entrez":"151","biology":"Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. Location: Cell membrane (UniProt). Locus 2q11.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/adra2b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}