{"entity":{"id":"adra2c","kind":"target","name":"ADRA2C","aka":["adrenoceptor alpha 2C","Alpha-2C adrenergic receptor","ADRARL2","ADRA2L2","ADRA2RL2"],"tldr":"ADRA2C (Alpha-2C adrenergic receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.40, clinical 0.81).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:283","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:283"},{"label":"UniProt P18825","url":"https://www.uniprot.org/uniprotkb/P18825/entry"},{"label":"NCBI Gene 152","url":"https://www.ncbi.nlm.nih.gov/gene/152"},{"label":"Ensembl ENSG00000184160","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184160"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.81. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ADRA2C","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:283","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:283","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P18825","url":"https://www.uniprot.org/uniprotkb/P18825/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000184160","url":"https://platform.opentargets.org/target/ENSG00000184160/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:283","ensembl":"ENSG00000184160","uniprot":"P18825","entrez":"152","biology":"Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity. The rank order of potency for physiological agonists of ADRA2C is epinephrine > norepinephrine > dopamine. Location: Cell membrane (UniProt). Locus 4p16.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/adra2c/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}