{"entity":{"id":"adv-101","kind":"drug","name":"ADV-101","aka":[],"tldr":"ADV-101 is an experimental antibody-drug conjugate from Advesya, at a stage the company does not state for cancer.","summary":"ADV-101 is an antibody-drug conjugate (humanised IgG1, cleavable linker, topoisomerase I inhibitor payload) from Advesya. A first-in-class antibody-drug conjugate: a humanised IgG1 antibody to IL-1RAP joined by a cleavable linker to a topoisomerase I inhibitor, released inside IL-1RAP-expressing cells after internalisation, with bystander killing nearby. The company does not state its stage; it is aimed at cancer. No clinical trial naming it is registered on ClinicalTrials.gov. The company gives no stage for ADV-101 and no registered trial was found (searched ADV-101, IL1RAP, IL-1RAP, Advesya); preclinical is inferred from the absence of a trial. It has not been shown to work in people.","asOf":"2026-11-03","links":[{"label":"Advesya: advesya.com","url":"https://advesya.com/our-science/"},{"label":"Advesya: advesya.com","url":"https://advesya.com/our-science/"}],"tags":["pipeline"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["advesya"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"ADV-101","modality":"Antibody-drug conjugate (humanised IgG1, cleavable linker, topoisomerase I inhibitor payload)","mechanism":"A first-in-class antibody-drug conjugate: a humanised IgG1 antibody to IL-1RAP joined by a cleavable linker to a topoisomerase I inhibitor, released inside IL-1RAP-expressing cells after internalisation, with bystander killing nearby.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/adv-101/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"advesya","kind":"company","name":"Advesya","route":"/companies/advesya/"}]}}