{"entity":{"id":"afdn","kind":"target","name":"AFDN","aka":["afadin, adherens junction formation factor","Afadin","AF-6","AF6","MLLT4"],"tldr":"AFDN (Afadin) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Colorectal cancer and 2 more.","summary":"Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organisation of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organisation of epithelial structures of the embryonic ectoderm.\n\nOpen Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.94, animal model 0.59, genetic association 0.00, somatic mutation 0.85). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Invasive Breast Carcinoma, Colorectal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7137","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7137"},{"label":"UniProt P55196","url":"https://www.uniprot.org/uniprotkb/P55196/entry"},{"label":"NCBI Gene 4301","url":"https://www.ncbi.nlm.nih.gov/gene/4301"},{"label":"Ensembl ENSG00000130396","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130396"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["breast-cancer","skin-cancer","colorectal","lung-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"AFDN","role":["oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:7137","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7137","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P55196","url":"https://www.uniprot.org/uniprotkb/P55196/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000130396","url":"https://platform.opentargets.org/target/ENSG00000130396/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: colorectal cancer 0.53, melanoma 0.55, skin cancer 0.58, breast cancer 0.57, lung cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen AFDN","url":"https://www.intogen.org/search?gene=AFDN","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:7137","ensembl":"ENSG00000130396","uniprot":"P55196","entrez":"4301","biology":"Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organisation of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organisation of epithelial structures of the embryonic ectoderm. Essential for the organisation of adherens junctions. Location: Cell junction, adherens junction (UniProt). Locus 6q27 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.57 with breast cancer (MONDO_0007254); IntOGen driver in 2 cohorts (BRCA)","Skin cancer: Open Targets association 0.58 with skin cancer (MONDO_0002898)","Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575); IntOGen driver in 1 cohort (COADREAD)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)","Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/afdn/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}