{"entity":{"id":"aff3","kind":"target","name":"AFF3","aka":["ALF transcription elongation factor 3","AF4/FMR2 family member 3","MLLT2-like","LAF4"],"tldr":"AFF3 (AF4/FMR2 family member 3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Thyroid cancer, Skin cancer and 4 more.","summary":"Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.87, animal model 0.46, genetic association 0.00, somatic mutation 0.84). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Lung Adenocarcinoma, Well-Differentiated Thyroid Cancer.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6473","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6473"},{"label":"UniProt P51826","url":"https://www.uniprot.org/uniprotkb/P51826/entry"},{"label":"NCBI Gene 3899","url":"https://www.ncbi.nlm.nih.gov/gene/3899"},{"label":"Ensembl ENSG00000144218","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000144218"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["breast-cancer","thyroid","skin-cancer","lung-cancer","gastric","nsclc","papillary-thyroid-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"AFF3","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6473","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6473","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P51826","url":"https://www.uniprot.org/uniprotkb/P51826/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000144218","url":"https://platform.opentargets.org/target/ENSG00000144218/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: gastric cancer 0.52, skin cancer 0.55, breast cancer 0.58, lung cancer 0.55 (GraphQL API, CC0)"},{"label":"IntOGen AFF3","url":"https://www.intogen.org/search?gene=AFF3","note":"driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6473","ensembl":"ENSG00000144218","uniprot":"P51826","entrez":"3899","biology":"Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. Location: Nucleus (UniProt). Locus 2q11.2 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254)","Thyroid cancer: IntOGen driver in 1 cohort (WDTC)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.55 with lung cancer (MONDO_0008903)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/aff3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"papillary-thyroid-cancer","kind":"cancer","name":"Papillary thyroid cancer","route":"/cancers/papillary-thyroid-cancer/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}