{"entity":{"id":"agenus","kind":"company","name":"Agenus","aka":["Agenus Inc.","Agenus Inc"],"tldr":"Agenus is a Massachusetts immuno-oncology company developing botensilimab, an Fc-enhanced anti-CTLA-4 antibody, with its anti-PD-1 balstilimab, notably in microsatellite-stable colorectal cancer where checkpoint inhibitors have not worked.","summary":"Agenus, based in Lexington, Massachusetts and listed on Nasdaq, develops checkpoint antibodies and cancer vaccines. Its lead combination is botensilimab, a next-generation anti-CTLA-4 antibody with an engineered Fc region, given with balstilimab, an anti-PD-1 antibody, which has shown responses in microsatellite-stable colorectal cancer without liver metastases and other cold tumours; the company has sought accelerated approval and runs registrational trials. OnCo records it as a registry sponsor of phase 3 cancer trials.","asOf":"2026-09-11","links":[{"label":"Official website","url":"https://agenusbio.com"},{"label":"ClinicalTrials.gov: trials led by Agenus","url":"https://clinicaltrials.gov/search?lead=Agenus"},{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Agenus"}],"tags":["ctgov-sponsor"],"related":[],"cancers":["colorectal"],"sections":["immunotherapy"],"technologies":[],"targets":["ctla4","pd1"],"drugs":["botensilimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"Lexington, MA","country":"US","companyType":"biotech","website":"https://agenusbio.com","stage":"public","investors":[],"funding":[]},"route":"/companies/agenus/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"section":[{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"}],"target":[{"id":"ctla4","kind":"target","name":"CTLA-4","route":"/targets/ctla4/"},{"id":"pd1","kind":"target","name":"PD-1","route":"/targets/pd1/"}],"drug":[{"id":"botensilimab","kind":"drug","name":"Botensilimab","route":"/drugs/botensilimab/"}]}}