{"entity":{"id":"aggf1","kind":"target","name":"AGGF1","aka":["angiogenic factor with G-patch and FHA domains 1","Angiogenic factor with G patch and FHA domains 1","VG5Q","HSU84971","FLJ10283","GPATC7","GPATCH7"],"tldr":"AGGF1 (Angiogenic factor with G patch and FHA domains 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.89, animal model 0.41, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:24684","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24684"},{"label":"UniProt Q8N302","url":"https://www.uniprot.org/uniprotkb/Q8N302/entry"},{"label":"NCBI Gene 55109","url":"https://www.ncbi.nlm.nih.gov/gene/55109"},{"label":"Ensembl ENSG00000164252","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164252"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"AGGF1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:24684","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24684","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8N302","url":"https://www.uniprot.org/uniprotkb/Q8N302/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000164252","url":"https://platform.opentargets.org/target/ENSG00000164252/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:24684","ensembl":"ENSG00000164252","uniprot":"Q8N302","entrez":"55109","biology":"Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. Location: Cytoplasm; Secreted (UniProt). Locus 5q13.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/aggf1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}