{"entity":{"id":"agk","kind":"target","name":"AGK","aka":["acylglycerol kinase","Acylglycerol kinase, mitochondrial","FLJ10842"],"tldr":"AGK (Acylglycerol kinase, mitochondrial) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.89, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21869","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21869"},{"label":"UniProt Q53H12","url":"https://www.uniprot.org/uniprotkb/Q53H12/entry"},{"label":"NCBI Gene 55750","url":"https://www.ncbi.nlm.nih.gov/gene/55750"},{"label":"Ensembl ENSG00000006530","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000006530"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"AGK","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:21869","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21869","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q53H12","url":"https://www.uniprot.org/uniprotkb/Q53H12/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000006530","url":"https://platform.opentargets.org/target/ENSG00000006530/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:21869","ensembl":"ENSG00000006530","uniprot":"Q53H12","entrez":"55750","biology":"Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide. Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol. Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force. Location: Mitochondrion inner membrane; Mitochondrion intermembrane space (UniProt). Locus 7q34 (HGNC).","whereFound":[],"targetClass":"kinase","prevalence":[]},"route":"/targets/agk/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}