{"entity":{"id":"agtrap","kind":"target","name":"AGTRAP","aka":["angiotensin II receptor associated protein","Type-1 angiotensin II receptor-associated protein","ATRAP"],"tldr":"AGTRAP (Type-1 angiotensin II receptor-associated protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitisation such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.89, animal model 0.26, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13539","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13539"},{"label":"UniProt Q6RW13","url":"https://www.uniprot.org/uniprotkb/Q6RW13/entry"},{"label":"NCBI Gene 57085","url":"https://www.ncbi.nlm.nih.gov/gene/57085"},{"label":"Ensembl ENSG00000177674","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177674"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"AGTRAP","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:13539","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13539","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6RW13","url":"https://www.uniprot.org/uniprotkb/Q6RW13/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000177674","url":"https://platform.opentargets.org/target/ENSG00000177674/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:13539","ensembl":"ENSG00000177674","uniprot":"Q6RW13","entrez":"57085","biology":"Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitisation such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. Location: Endoplasmic reticulum membrane; Golgi apparatus membrane; Cytoplasmic vesicle membrane (UniProt). Locus 1p36.22 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/agtrap/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}