{"entity":{"id":"ai-pathology-scoring","kind":"technology","name":"AI scoring of biomarkers and grade on pathology slides","aka":[],"tldr":"Software that reads digitised biopsy slides to detect cancer, grade it, and score biomarkers such as HER2, PD-L1 and Ki-67 more consistently than the eye alone.","summary":"Deep-learning models trained on whole-slide images now detect prostate cancer in biopsies (Paige Prostate, the first FDA-authorised AI pathology tool, 2021), assist Gleason grading, count mitoses, and quantify immunohistochemistry such as HER2, PD-L1 and Ki-67, where pathologist agreement is known to be poor at the decision thresholds. Newer models infer molecular states, such as microsatellite instability, directly from routine H&E slides.","status":"approved","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Digital_pathology","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Digital_pathology"}],"tags":[],"related":[],"cancers":["prostate","breast-her2-positive","nsclc"],"sections":["diagnostics","ai-computation"],"technologies":["digital-pathology-ai","tmb-testing"],"targets":[],"drugs":[],"companies":["vicinity-bio"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":["digital-pathology-ai"],"notes":[],"principle":"Convolutional or transformer networks trained on annotated whole-slide images produce per-region probabilities that are aggregated into detections, grades or scores presented to the pathologist.","strengths":["Reduces scoring variability at treatment thresholds","Triages slides and flags missed foci","Can infer molecular features from H&E alone"],"limitations":["Performance depends on scanner and stain domain","Regulatory clearance is product by product","Pathologist remains responsible for the diagnosis"],"since":2021},"route":"/technologies/ai-pathology-scoring/","neighbours":{"cancer":[{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"},{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"digital-pathology-ai","kind":"technology","name":"Digital pathology & AI","route":"/technologies/digital-pathology-ai/"},{"id":"tmb-testing","kind":"technology","name":"Tumour mutational burden testing","route":"/technologies/tmb-testing/"}],"company":[{"id":"vicinity-bio","kind":"company","name":"Vicinity Bio","route":"/companies/vicinity-bio/"}]}}