{"entity":{"id":"aimp2","kind":"target","name":"AIMP2","aka":["aminoacyl tRNA synthetase complex interacting multifunctional protein 2","Aminoacyl tRNA synthase complex-interacting multifunctional protein 2","p38","PRO0992","JTV-1","JTV1"],"tldr":"AIMP2 (Aminoacyl tRNA synthase complex-interacting multifunctional protein 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer.","summary":"Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20609","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20609"},{"label":"UniProt Q13155","url":"https://www.uniprot.org/uniprotkb/Q13155/entry"},{"label":"NCBI Gene 7965","url":"https://www.ncbi.nlm.nih.gov/gene/7965"},{"label":"Ensembl ENSG00000106305","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106305"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"AIMP2","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:20609","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20609","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13155","url":"https://www.uniprot.org/uniprotkb/Q13155/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene AIMP2","url":"https://civicdb.org/features/6394","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:20609","ensembl":"ENSG00000106305","uniprot":"Q13155","entrez":"7965","biology":"Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. Location: Cytoplasm, cytosol; Nucleus (UniProt). Locus 7p22.1 (HGNC).","whereFound":["Lung cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/aimp2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"}]}}