{"entity":{"id":"al-433","kind":"drug","name":"AL-433","aka":[],"tldr":"AL-433 is an experimental small molecule from Alaw Therapeutics, in preclinical development for solid tumours.","summary":"AL-433 is a small molecule from Alaw Therapeutics. A selective, brain-penetrant CDK4 inhibitor engineered for selectivity over CDK6, intended to reduce CDK6-related blood toxicity; it targets tumours driven by the CDK4-cyclin D1-Rb-E2F axis. Its furthest stage is preclinical development, for solid tumours (indication not specified). No clinical trial naming it is registered on ClinicalTrials.gov. Nominated as a development candidate on 29 May 2026; first-in-human studies planned for the fourth quarter of 2026. No registered trial found. It has not been shown to work in people.","status":"preclinical","asOf":"2026-11-03","links":[{"label":"Alaw Therapeutics: alawtx.com","url":"https://www.alawtx.com/news1/alaw-therapeutics-announces-two-major-pipeline-milestones-advancing-brain-penetrant-cdk-oncology-programs"},{"label":"Alaw Therapeutics: alawtx.com","url":"https://www.alawtx.com/news1/alaw-therapeutics-announces-two-major-pipeline-milestones-advancing-brain-penetrant-cdk-oncology-programs"}],"tags":["pipeline"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["alaw-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"AL-433","modality":"Small molecule","mechanism":"A selective, brain-penetrant CDK4 inhibitor engineered for selectivity over CDK6, intended to reduce CDK6-related blood toxicity; it targets tumours driven by the CDK4-cyclin D1-Rb-E2F axis.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/al-433/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"alaw-therapeutics","kind":"company","name":"Alaw Therapeutics","route":"/companies/alaw-therapeutics/"}]}}