{"entity":{"id":"ala-105","kind":"drug","name":"ALA-105","aka":["CLDN18.2-iNKT"],"tldr":"ALA-105 is an experimental CAR-iNKT cell therapy with IL-12 armouring from Arovella Therapeutics, at a stage the company does not state for gastric cancer, gastro-oesophageal junction cancer and pancreatic cancer.","summary":"ALA-105 (CLDN18.2-iNKT) is a CAR-iNKT cell therapy with IL-12 armouring from Arovella Therapeutics, with Sparx Group as partner. iNKT cells carrying a CAR built from Sparx's anti-CLDN18.2 antibody SPX-101, armoured with membrane-tethered IL-12 (IL-12-TM) to improve persistence in solid tumours. The company does not state its stage; it is aimed at gastric cancer, gastro-oesophageal junction cancer and pancreatic cancer. No clinical trial naming it is registered on ClinicalTrials.gov. No registry trial found (ClinicalTrials.gov query for ALA-105 returned none); the company page gives no stage, so 'preclinical' is inferred from the absence of any trial. It has not been shown to work in people.","asOf":"2026-11-03","links":[{"label":"Arovella Therapeutics: arovella.com","url":"https://www.arovella.com/ala-105-cldn182-inkt"},{"label":"Arovella Therapeutics: arovella.com","url":"https://www.arovella.com/ala-105-cldn182-inkt"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":["cldn18-2"],"drugs":[],"companies":["arovella-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"ALA-105","modality":"CAR-iNKT cell therapy with IL-12 armouring","mechanism":"iNKT cells carrying a CAR built from Sparx's anti-CLDN18.2 antibody SPX-101, armoured with membrane-tethered IL-12 (IL-12-TM) to improve persistence in solid tumours.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/ala-105/","neighbours":{"target":[{"id":"cldn18-2","kind":"target","name":"Claudin 18.2","route":"/targets/cldn18-2/"}],"company":[{"id":"arovella-therapeutics","kind":"company","name":"Arovella Therapeutics","route":"/companies/arovella-therapeutics/"}]}}