{"entity":{"id":"alliance-n0574","kind":"trial","name":"Alliance N0574 (NCCTG N0574)","aka":[],"tldr":"N0574 showed that adding whole-brain radiotherapy to radiosurgery for a few brain metastases damages memory and thinking without lengthening life, and radiosurgery alone became the standard.","summary":"N0574 randomised 213 patients with one to three brain metastases to stereotactic radiosurgery alone or radiosurgery plus whole-brain radiotherapy. Cognitive deterioration at three months, the primary endpoint, occurred in 63.5 percent after radiosurgery alone and 91.7 percent after the combination; whole-brain treatment improved intracranial control but median survival did not differ (10.4 vs 7.4 months, not significant) (Brown and colleagues, JAMA 2016).","status":"positive","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT00377156","url":"https://clinicaltrials.gov/study/NCT00377156"},{"label":"JAMA 2016","url":"https://doi.org/10.1001/jama.2016.9839"}],"tags":["radiation-wave2"],"related":[],"cancers":["brain-tumours","metastatic-cancer"],"sections":[],"technologies":["radiosurgery-srs"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["wbrt","stereotactic-radiosurgery"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT00377156","phase":"3","setting":"One to three brain metastases: stereotactic radiosurgery alone versus radiosurgery plus whole-brain radiotherapy","sponsor":"Alliance for Clinical Trials in Oncology","result":"Cognitive deterioration at 3 months 63.5% (SRS alone) vs 91.7% (SRS plus WBRT); no survival difference.","yearReported":2016,"enrolled":213,"outcomes":[{"endpoint":"Cognitive deterioration at 3 months","primary":true,"unit":"%","arms":[{"name":"Radiosurgery alone","n":111,"value":63.5},{"name":"Radiosurgery plus whole-brain radiotherapy","n":102,"value":91.7}]}]},"route":"/trials/alliance-n0574/","neighbours":{"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"technology":[{"id":"radiosurgery-srs","kind":"technology","name":"Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS)","route":"/technologies/radiosurgery-srs/"}],"term":[{"id":"stereotactic-radiosurgery","kind":"term","name":"Stereotactic radiosurgery (SRS)","route":"/terms/stereotactic-radiosurgery/"},{"id":"wbrt","kind":"term","name":"Whole-brain radiotherapy (WBRT)","route":"/terms/wbrt/"}]}}