{"entity":{"id":"alphaparp","kind":"drug","name":"AlphaPARP","aka":["[211At]PTT","211At-Parthanatine","Astatine-211 parthanatine"],"tldr":"AlphaPARP is an experimental radioactive drug from Trevarx Biomedical that carries an alpha-emitting atom to the DNA-repair enzyme PARP1 in cancer cells. It is being prepared for a first trial in ovarian cancer.","summary":"AlphaPARP ([211At]PTT) is Trevarx Biomedical's first therapeutic. The company states that its effect comes from DNA-proximal alpha energy deposition rather than from PARP inhibition itself. A 2026 National Cancer Institute SBIR award funds IND-enabling work for a phase 1 study in ovarian cancer, with a fluorine-18 companion imaging agent for patient selection. No registered trial was found.","status":"preclinical","asOf":"2026-11-04","links":[{"label":"Trevarx Biomedical","url":"https://www.trevarx.com/"},{"label":"NIH RePORTER: award 1R44CA310342-01A1","url":"https://reporter.nih.gov/project-details/11408032"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":[],"technologies":["astatine-211-alpha-therapy","targeted-alpha-therapy"],"targets":["parp"],"drugs":[],"companies":["trevarx-biomedical"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors","editedOn":"2026-11-04"},"modality":"Targeted alpha radiopharmaceutical (small molecule)","mechanism":"Astatine-211 covalently attached to a PARP inhibitor analogue (Parthanatine) that binds activated PARP1 at sites of tumour DNA damage, so the alpha particle is emitted beside the DNA and causes double-strand breaks, as described by Trevarx Biomedical.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/alphaparp/","neighbours":{"technology":[{"id":"astatine-211-alpha-therapy","kind":"technology","name":"Astatine-211 alpha therapy","route":"/technologies/astatine-211-alpha-therapy/"},{"id":"targeted-alpha-therapy","kind":"technology","name":"Targeted alpha therapy","route":"/technologies/targeted-alpha-therapy/"}],"target":[{"id":"parp","kind":"target","name":"PARP","route":"/targets/parp/"}],"company":[{"id":"trevarx-biomedical","kind":"company","name":"Trevarx Biomedical","route":"/companies/trevarx-biomedical/"}]}}