{"entity":{"id":"ambry-brcaplus","kind":"drug","name":"BRCAplus (Ambry Genetics)","aka":["BRCAPlus","Ambry BRCAplus"],"tldr":"A blood test from Ambry Genetics for 13 genes linked to inherited breast cancer, including BRCA1, BRCA2, PALB2 and TP53.","summary":"Registered in the NIH Genetic Testing Registry as GTR000560503.11 (updated 12 November 2024) by Ambry Genetics: ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11 and TP53. Recorded as a test developed by the laboratory; not among the FDA-authorised hereditary cancer products.","status":"established","asOf":"2026-11-04","links":[{"label":"NIH Genetic Testing Registry GTR000560503.11","url":"https://www.ncbi.nlm.nih.gov/gtr/tests/560503/"},{"label":"NIH Genetic Testing Registry data file (test_version.gz)","url":"https://ftp.ncbi.nlm.nih.gov/pub/GTR/data/test_version.gz"}],"tags":["test","hereditary"],"related":[],"cancers":[],"sections":[],"technologies":["germline-testing"],"targets":["brca","palb2","atm","chek2","tp53","cdh1","pten","rad51c","rad51d","stk11","nf1"],"drugs":[],"companies":["ambry-genetics"],"institutions":[],"pathways":[],"terms":["gbrca-mutation","hereditary-cancer-syndromes","hereditary-diffuse-gastric-cancer"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"brand":"BRCAplus","modality":"Germline breast cancer gene panel (laboratory-developed test)","mechanism":"Next-generation sequencing of 13 breast cancer susceptibility genes in germline DNA.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/ambry-brcaplus/","neighbours":{"technology":[{"id":"germline-testing","kind":"technology","name":"Germline (hereditary) testing","route":"/technologies/germline-testing/"}],"target":[{"id":"atm","kind":"target","name":"ATM","route":"/targets/atm/"},{"id":"brca","kind":"target","name":"BRCA1 / BRCA2 (HRD)","route":"/targets/brca/"},{"id":"cdh1","kind":"target","name":"CDH1","route":"/targets/cdh1/"},{"id":"chek2","kind":"target","name":"CHEK2","route":"/targets/chek2/"},{"id":"nf1","kind":"target","name":"NF1 (neurofibromin)","route":"/targets/nf1/"},{"id":"palb2","kind":"target","name":"PALB2","route":"/targets/palb2/"},{"id":"pten","kind":"target","name":"PTEN","route":"/targets/pten/"},{"id":"rad51c","kind":"target","name":"RAD51C","route":"/targets/rad51c/"},{"id":"rad51d","kind":"target","name":"RAD51D","route":"/targets/rad51d/"},{"id":"stk11","kind":"target","name":"STK11","route":"/targets/stk11/"},{"id":"tp53","kind":"target","name":"TP53","route":"/targets/tp53/"}],"company":[{"id":"ambry-genetics","kind":"company","name":"Ambry Genetics","route":"/companies/ambry-genetics/"}],"term":[{"id":"gbrca-mutation","kind":"term","name":"Germline BRCA mutation (gBRCA)","route":"/terms/gbrca-mutation/"},{"id":"hereditary-cancer-syndromes","kind":"term","name":"Hereditary cancer syndromes","route":"/terms/hereditary-cancer-syndromes/"},{"id":"hereditary-diffuse-gastric-cancer","kind":"term","name":"Hereditary diffuse gastric cancer","route":"/terms/hereditary-diffuse-gastric-cancer/"}]}}