{"entity":{"id":"ambry-cancernext","kind":"drug","name":"CancerNext and CancerNext-Expanded (Ambry Genetics)","aka":["CancerNext","CancerNext-Expanded","Ambry CancerNext"],"tldr":"Ambry Genetics' multi-gene blood tests for inherited cancer risk: CancerNext covers 41 genes and CancerNext-Expanded 90, ordered through a clinician.","summary":"Registered in the NIH Genetic Testing Registry by Ambry Genetics (CLIA 05D0981414): CancerNext, GTR000560509.15 (41 genes, version updated 19 May 2026), and CancerNext-Expanded, GTR000560508.11 (90 genes, updated 14 February 2025), which adds genes for haematological predisposition (DDX41, RUNX1, GATA2, CEBPA, ETV6), pancreatitis (PRSS1, SPINK1, CTRC, CPA1), paraganglioma, rhabdoid tumour and others. Versions with paired RNA analysis (RNAinsight) are registered separately. GTR records them as tests developed by the laboratory; they are not among the FDA-authorised hereditary cancer products.","status":"established","asOf":"2026-11-04","links":[{"label":"NIH Genetic Testing Registry GTR000560509.15","url":"https://www.ncbi.nlm.nih.gov/gtr/tests/560509/"},{"label":"NIH Genetic Testing Registry GTR000560508.11","url":"https://www.ncbi.nlm.nih.gov/gtr/tests/560508/"},{"label":"NIH Genetic Testing Registry data file (test_version.gz)","url":"https://ftp.ncbi.nlm.nih.gov/pub/GTR/data/test_version.gz"}],"tags":["test","hereditary"],"related":[],"cancers":[],"sections":[],"technologies":["germline-testing"],"targets":["brca","palb2","mlh1","msh2","ddx41","runx1","gata2"],"drugs":[],"companies":["ambry-genetics"],"institutions":[],"pathways":[],"terms":["hereditary-cancer-syndromes","lynch-syndrome","germline-myeloid-predisposition","peutz-jeghers-syndrome"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"brand":"CancerNext","modality":"Germline hereditary cancer sequencing panel (laboratory-developed test)","mechanism":"Next-generation sequencing of germline DNA: 41 genes in CancerNext and 90 in CancerNext-Expanded, each also offered with paired RNA analysis.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/ambry-cancernext/","neighbours":{"technology":[{"id":"germline-testing","kind":"technology","name":"Germline (hereditary) testing","route":"/technologies/germline-testing/"}],"target":[{"id":"brca","kind":"target","name":"BRCA1 / BRCA2 (HRD)","route":"/targets/brca/"},{"id":"ddx41","kind":"target","name":"DDX41","route":"/targets/ddx41/"},{"id":"gata2","kind":"target","name":"GATA2","route":"/targets/gata2/"},{"id":"mlh1","kind":"target","name":"MLH1","route":"/targets/mlh1/"},{"id":"msh2","kind":"target","name":"MSH2","route":"/targets/msh2/"},{"id":"palb2","kind":"target","name":"PALB2","route":"/targets/palb2/"},{"id":"runx1","kind":"target","name":"RUNX1","route":"/targets/runx1/"}],"company":[{"id":"ambry-genetics","kind":"company","name":"Ambry Genetics","route":"/companies/ambry-genetics/"}],"term":[{"id":"germline-myeloid-predisposition","kind":"term","name":"Germline predisposition to myeloid neoplasms (inherited predisposition to AML and MDS)","route":"/terms/germline-myeloid-predisposition/"},{"id":"hereditary-cancer-syndromes","kind":"term","name":"Hereditary cancer syndromes","route":"/terms/hereditary-cancer-syndromes/"},{"id":"lynch-syndrome","kind":"term","name":"Lynch syndrome","route":"/terms/lynch-syndrome/"},{"id":"peutz-jeghers-syndrome","kind":"term","name":"Peutz-Jeghers syndrome","route":"/terms/peutz-jeghers-syndrome/"}]}}