{"entity":{"id":"ankrd11","kind":"target","name":"ANKRD11","aka":["ankyrin repeat domain 11","Ankyrin repeat domain-containing protein 11","LZ16","T13","ANCO1","ANCO-1"],"tldr":"ANKRD11 (Ankyrin repeat domain-containing protein 11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.","summary":"Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells. May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Malignant Lymphoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21316","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21316"},{"label":"UniProt Q6UB99","url":"https://www.uniprot.org/uniprotkb/Q6UB99/entry"},{"label":"NCBI Gene 29123","url":"https://www.ncbi.nlm.nih.gov/gene/29123"},{"label":"Ensembl ENSG00000167522","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167522"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ANKRD11","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:21316","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21316","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6UB99","url":"https://www.uniprot.org/uniprotkb/Q6UB99/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ANKRD11","url":"https://www.intogen.org/search?gene=ANKRD11","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:21316","ensembl":"ENSG00000167522","uniprot":"Q6UB99","entrez":"29123","biology":"Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells. May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis. Location: Nucleus (UniProt). Locus 16q24.3 (HGNC).","whereFound":["Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (MLYM)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/ankrd11/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}