{"entity":{"id":"ano7","kind":"target","name":"ANO7","aka":["anoctamin 7","Anoctamin-7","PCANAP5L","IPCA-5","PCANAP5","TMEM16G"],"tldr":"ANO7 (Anoctamin-7) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.73).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:31677","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31677"},{"label":"UniProt Q6IWH7","url":"https://www.uniprot.org/uniprotkb/Q6IWH7/entry"},{"label":"NCBI Gene 50636","url":"https://www.ncbi.nlm.nih.gov/gene/50636"},{"label":"Ensembl ENSG00000146205","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000146205"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ANO7","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:31677","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31677","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6IWH7","url":"https://www.uniprot.org/uniprotkb/Q6IWH7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000146205","url":"https://platform.opentargets.org/target/ENSG00000146205/associations","note":"association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: prostate cancer 0.57 (GraphQL API, CC0)"}],"hgnc":"HGNC:31677","ensembl":"ENSG00000146205","uniprot":"Q6IWH7","entrez":"50636","biology":"Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions. Location: Cell membrane; Cell junction; Endoplasmic reticulum; Cytoplasm, cytosol (UniProt). Locus 2q37.3 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.57 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/ano7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}